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SOCIAL AND BEHAVIORAL CHARACTERISTICS OF MALE BLOOD DONORS AND THEIR SEXUAL PARTNERS: AN ANALYSIS TO DEFINE RISK SUBSETS
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June 03 2019
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Source: Transfusion. 59(8):2584-2592
[PDF-220.59 KB]
Details:
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Alternative Title:Transfusion
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Description:Background
Men who have sex with men (MSM) in Brazil are deferred from donation for 1-year since last sexual contact. Legal proceedings in front of the Brazilian Supreme Court could compel blood collection agencies to discontinue use of sexual orientation questions.
Methods
Data from male participants in a completed HIV risk factor case-control study were used to evaluate whether it is possible to differentiate donors at lower and higher risk for HIV using two analytical approaches latent class and random forest analyses.
Results
Male blood donors were divided into three distinct risk profile classes: Class-1 with donors who are heterosexual (96.4%), HIV− (88.7%), have a main partner (99.4%), and practice unprotected sex (77.8%). Class-2 with donors who are MSM/bisexuals’ donors (100.0%), HIV+ (97.4%), and were not aware of their sexual partners’ HIV status (80.3%). Class-3 with donors who were heterosexual (84.1%), practicing unprotected vaginal/anal heterosexual sex (66.8% vs 40.9%), and were both HIV+ and HIV− (49.5% vs. 50.5%). We also found that asking donors about their partner(s) HIV serostatus could replace asking about donor’s sexual orientation and types of partners with relatively minor shifts in sensitivity (0.76 vs. 0.58), specificity (0.89 vs. 0.94) and positive predictive value (PPV) (0.85 vs. 0.88).
Conclusion
Sexual orientation questions on the donor questionnaire could be replaced without great loss in the sensitivity, specificity and PPV. Social and sexual behaviors of donors and their partners are proxies for HIV risk and can help to develop modified questions that will need controlled trials to be validated.
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Pubmed ID:31158312
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Pubmed Central ID:PMC6679786
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Funding:
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Volume:59
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Issue:8
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