Shift Work and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Details

• Alternative Title:
  J Occup Environ Med
• Personal Author:
  Holst, Meghan M. ; Wirth, Michael D. ; Mnatsakanova, Anna ; Burch, James B. ; Charles, Luenda E. ; Tinney-Zara, Cathy ; Fekedulegn, Desta ; Andrew, Michael E. ; Hartley, Tara A. ; Violanti, John M.
• Description:
  Objective:
  
  To assess the association of shift work with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.
  
  Methods:
  
  A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.
  
  Results:
  
  Associations were observed between day and night shift workers for leukocytes, tumor necrosis factor alpha and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shift workers with a BMI ≥ 30 kg/m2 versus the day shift.
  
  Conclusions:
  
  Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shift work.
  
  
• Subjects:
  Adult Biomarkers Body Mass Index Cardiovascular Diseases Cross-Sectional Studies Humans Male Middle Aged Police Work Schedule Tolerance
• Source:
  J Occup Environ Med. 61(5):391-396
• Pubmed ID:
  30649009
• Pubmed Central ID:
  PMC6610651
• Document Type:
  Journal Article
• Funding:
  R01 OH009640/OH/NIOSH CDC HHS/United States ; R01 OH010807/OH/NIOSH CDC HHS/United States ; R01OH010807/ACL HHS/United States
• Volume:
  61
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:fb36dd9a22e53e60835a75b7ee21f9a64fbd9b83a585928ff746c7df21ca56c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/79699/cdc_79699_DS1.pdf
• File Type:
  [PDF - 351.91 KB ]