J Occup Environ Med

Objective: To assess the association of shift work with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort. Methods: A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification. Results: Associations were observed between day and night shift workers for leukocytes, tumor necrosis factor alpha and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shift workers with a BMI ≥ 30 kg/m2 versus the day shift. Conclusions: Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shift work.

30649009

PMC6610651

CDC Public Access