Shift Work and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Holst, Meghan M.; Wirth, Michael D.; Mnatsakanova, Anna; Burch, James B.; Charles, Luenda E.; Tinney-Zara, Cathy; Fekedulegn, Desta; Andrew, Michael E.; Hartley, Tara A.; Violanti, John M.

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Shift Work and Biomarkers of Subclinical Cardiovascular Disease: The BCOPS Study

Published Date:

May 2019

Source:

J Occup Environ Med. 61(5):391-396

Language:

English

[PDF-351.91 KB]

Details:

Alternative Title:

J Occup Environ Med

Personal Author:

Holst, Meghan M. ; Wirth, Michael D. ; Mnatsakanova, Anna ; Burch, James B. ; Charles, Luenda E. ; ... More ▼

Description:

Objective:

To assess the association of shift work with biomarkers of subclinical cardiovascular disease and examine the moderating role of body mass index (BMI) in a police cohort.

Methods:

A cross-sectional analysis was conducted among officers who were categorized as working the day, evening, or night shift. Comparisons with inflammatory biomarkers were performed among shifts using analysis of variance/covariance and further stratified by BMI to assess potential effect modification.

Results:

Associations were observed between day and night shift workers for leukocytes, tumor necrosis factor alpha and homocysteine. After BMI stratification, higher c-reactive protein (CRP) levels were observed among evening shift workers with a BMI ≥ 30 kg/m2 versus the day shift.

Conclusions:

Future studies examining prospective changes in these markers will allow for more comprehensive evaluation of their association with shift work.

Subject:

[+]

Pubmed ID:

30649009

Pubmed Central ID:

PMC6610651

Document Type:

Journal Article

Funding:

R01 OH009640/OH/NIOSH CDC HHS/United States ; R01 OH010807/OH/NIOSH CDC HHS/United States ; R01OH010807/ACL HHS/United States ;

Collection(s):

CDC Public Access

Main Document Checksum:

[+]

Supporting Files:

nihms-1518217.nxml

text/xml

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