Safety of a meningococcal group B vaccine used in response to two university outbreaks

Details

• Alternative Title:
  J Am Coll Health
• Personal Author:
  Duffy, Jonathan ; Johnsen, Peter ; Ferris, Mary ; Miller, Mary ; Leighton, Kevin ; McGilvray, Mark ; McNamara, Lucy ; Breakwell, Lucy ; Yu, Yon ; Bhavsar, Tina ; Briere, Elizabeth ; Patel, Manisha
• Description:
  Objective:
  
  To assess the safety of meningococcal group B (MenB)-4C vaccine.
  
  Participants:
  
  Undergraduates, dormitory residents, and persons with high-risk medical conditions received the MenB-4C vaccine two-dose series during mass vaccination clinics from 12/2013 through 11/2014.
  
  Methods:
  
  Adverse events (AEs) were identified by 15 minutes of observation postvaccination, spontaneous reports, surveys, and hospital surveillance. Causality was assessed for serious adverse events (SAEs).
  
  Results:
  
  16,974 persons received 31,313 MenB-4C doses. The incidence of syncope during the 15-minutes post-dose 1 was 0.88/1000 persons. 2% of participants spontaneously reported an AE (most common were arm pain and fever). 3 SAEs were suspected of being caused by the vaccine, including one case of anaphylaxis.
  
  Conclusions:
  
  Most AEs reported were nonserious and consistent with previous clinical trial findings. Measures to prevent injury from syncope and to treat anaphylaxis should be available wherever vaccines are administered. Our safety evaluation supports the use of MenB-4C in response to outbreaks.
  
  
• Subjects:
  Adult Article Disease Outbreaks Female Humans Incidence Latex Hypersensitivity Male Meningococcal Infections Meningococcal Vaccines Neisseria Meningitidis Neisseria Meningitidis, Serogroup B Pharmacovigilance Postvaccination Syncope Serogroup B Student Health Services Students Surveys And Questionnaires Universities

  More +
• Source:
  J Am Coll Health. 65(6):380-388
• Pubmed ID:
  28362241
• Pubmed Central ID:
  PMC6574050
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  65
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:b42df1f6384ee02b8f08dca65b670f122c8a81937d4799c85eda5569d6bb3d0f
• Download URL:
  https://stacks.cdc.gov/view/cdc/79140/cdc_79140_DS1.pdf
• File Type:
  [PDF - 86.87 KB ]