Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study

Howley, Meredith M.; Feldkamp, Marcia L.; Papadopoulos, Eleni A.; Fisher, Sarah C.; Arnold, Kathryn E.; Browne, Marilyn L.

doi:10.1002/bdr2.1409

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study

11 15 2018
By Howley, Meredith M. ; Feldkamp, Marcia L. ; Papadopoulos, Eleni A. ; ...
http://dx.doi.org/10.1002/bdr2.1409
Source: Birth Defects Res. 110(19):1443-1454

[PDF-297.43 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Birth Defects Res
Personal Author:

Howley, Meredith M. ; Feldkamp, Marcia L. ; Papadopoulos, Eleni A. ; Fisher, Sarah C. ; Arnold, Kathryn E. ; ... More +

Howley, Meredith M. ; Feldkamp, Marcia L. ; Papadopoulos, Eleni A. ; Fisher, Sarah C. ; Arnold, Kathryn E. ; Browne, Marilyn L. Less -
Corporate Authors:

National Birth Defects Prevention Study
Description:

Background

Genitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs.

Methods

Using data from the National Birth Defects Prevention Study, a multisite, population-based, case-control study, we assessed self-reported maternal GUIs in the month before through the third month of pregnancy (periconception) from 29,316 birth defect cases and 11,545 unaffected controls. We calculated odds ratios (ORs) and 95% confidence intervals to estimate the risk of 52 major structural birth defects associated with GUIs. We also calculated risk of birth defects associated with each type of GUI: urinary tract infection (UTI) and sexually transmitted infection (STI).

Results

In our analysis, 10% (n = 2,972) of case and 9% (n = 1,014) of control mothers reported a periconceptional GUI. A GUI was significantly associated with 11 of the 52 birth defects examined (ORs ranging from 1.19 to 2.26): encephalocele, cataracts, cleft lip, esophageal atresia, duodenal atresia/stenosis, small intestinal atresia/stenosis, colonic atresia/stenosis, transverse limb deficiency, conoventricular septal defect, atrioventricular septal defect, and secundum atrial septal defect. A periconceptional UTI was significantly associated with nine birth defects (ORs from 1.21 to 2.48), and periconceptional STI was significantly associated with four birth defects (ORs ranging from 1.63 to 3.72).

Conclusions

While misclassification of GUIs in our analysis is likely, our findings suggest GUIs during the periconceptional period may increase the risk for specific birth defects.
Subjects:

[+]

Adult Case-Control Studies Congenital Abnormalities Female Humans Infant, Low Birth Weight Infant, Newborn Logistic Models Male Mothers Odds Ratio Population Surveillance Pregnancy Pregnancy Trimester, First Prenatal Exposure Delayed Effects Reproductive Tract Infections Risk Factors Self Report Urinary Tract Infections
Keywords:

[+]

Birth Defects Chlorination Congenital Malformations Genitourinary Infections Household Water Treatment Infections Safe Water Storage Sexually Transmitted Infections Urinary Tract Infection
Source:

Birth Defects Res. 110(19):1443-1454
Pubmed ID:

30402975
Pubmed Central ID:

PMC6543540
Document Type:

Journal Article
Funding:

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01DD001032/ACL/ACL HHSUnited States/ ; U01DD001032/DD/NCBDD CDC HHSUnited States/ ; U01DD001032/CC/CDC HHSUnited States/

CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01DD001032/ACL/ACL HHSUnited States/ ; U01DD001032/DD/NCBDD CDC HHSUnited States/ ; U01DD001032/CC/CDC HHSUnited States/ Less -
Volume:

110
Issue:

19
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:51a34d5db3086a60311df2115363ec9dead1adfad935fc26d5a97b9a09edb855
Download URL:

https://stacks.cdc.gov/view/cdc/78855/cdc_78855_DS1.pdf
File Type:

	nihms-1010635-f0001.gif	gif
	nihms-1010635-f0001.jpg	jpeg
	nihms-1010635.nxml	xml
	NIHMS1010635-supplement-1.pdf	pdf

More +