Maternal genitourinary infections and risk of birth defects in the National Birth Defects Prevention Study

Details

• Alternative Title:
  Birth Defects Res
• Personal Author:
  Howley, Meredith M. ; Feldkamp, Marcia L. ; Papadopoulos, Eleni A. ; Fisher, Sarah C. ; Arnold, Kathryn E. ; Browne, Marilyn L.
• Corporate Authors:
  National Birth Defects Prevention Study
• Description:
  Background ; Genitourinary infections (GUIs) are common among sexually active women. Yet, little is known about the risk of birth defects associated with GUIs. ; Methods ; Using data from the National Birth Defects Prevention Study, a multisite, population-based, case-control study, we assessed self-reported maternal GUIs in the month before through the third month of pregnancy (periconception) from 29,316 birth defect cases and 11,545 unaffected controls. We calculated odds ratios (ORs) and 95% confidence intervals to estimate the risk of 52 major structural birth defects associated with GUIs. We also calculated risk of birth defects associated with each type of GUI: urinary tract infection (UTI) and sexually transmitted infection (STI). ; Results ; In our analysis, 10% (n = 2,972) of case and 9% (n = 1,014) of control mothers reported a periconceptional GUI. A GUI was significantly associated with 11 of the 52 birth defects examined (ORs ranging from 1.19 to 2.26): encephalocele, cataracts, cleft lip, esophageal atresia, duodenal atresia/stenosis, small intestinal atresia/stenosis, colonic atresia/stenosis, transverse limb deficiency, conoventricular septal defect, atrioventricular septal defect, and secundum atrial septal defect. A periconceptional UTI was significantly associated with nine birth defects (ORs from 1.21 to 2.48), and periconceptional STI was significantly associated with four birth defects (ORs ranging from 1.63 to 3.72). ; Conclusions ; While misclassification of GUIs in our analysis is likely, our findings suggest GUIs during the periconceptional period may increase the risk for specific birth defects.
• Subjects:
  • Adult
  • Case-Control Studies
  • Congenital Abnormalities
  • Female
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Logistic Models
  • Male
  • Mothers
  More +
• Keywords:
  • birth defects
  • congenital malformations
  • genitourinary infections
  • infections
  • sexually transmitted infections
  • urinary tract infection
  • Chlorination
  • Household water treatment
  • Safe water storage
• Source:
  Birth Defects Res. 110(19):1443-1454
• Pubmed ID:
  30402975
• Pubmed Central ID:
  PMC6543540
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; U01DD001032/ACL/ACL HHSUnited States/ ; U01DD001032/DD/NCBDD CDC HHSUnited States/ ; U01DD001032/CC/CDC HHSUnited States/
• Volume:
  110
• Issue:
  19
• Download URL:
  https://stacks.cdc.gov/view/cdc/78855/cdc_78855_DS1.pdf
• File Type:
  [PDF - 297.43 KB]
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:51a34d5db3086a60311df2115363ec9dead1adfad935fc26d5a97b9a09edb855