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Major birth defects after vaccination reported to the Vaccine Adverse Event Reporting System (VAERS), 1990 - 2014
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Jul 17 2017
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Source: Birth Defects Res. 109(13):1057-1062
[PDF-59.41 KB]
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Alternative Title:Birth Defects Res
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Description:Background:
Major birth defects are important infant outcomes that have not been well studied in the post-marketing surveillance of vaccines given to pregnant women. We assessed the presence of major birth defects following vaccination in the Vaccine Adverse Event Reporting System, a national spontaneous reporting system used to monitor the safety of vaccines in the United States.
Methods:
We searched the VAERS database for reports of major birth defects during 1/1/1990 through 12/31/2014. We excluded birth defects from vaccines that had been studied in pregnancy registries or other epidemiological studies.
Results:
We identified 50 reports of major birth defects; in 28 reports, the vaccine was given during the first trimester. Birth defects accounted for 0.03% of all reports received by VAERS during the study period; reported defects affected predominately the musculoskeletal (N=10) or nervous (N=10) systems. No unusual clusters or specific birth defects were identified after any vaccine evaluated.
Conclusion:
This review of the VAERS database found that major birth defects were infrequently reported, with no particular condition reported disproportionally.
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Pubmed ID:28762675
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Pubmed Central ID:PMC6528469
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Volume:109
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Issue:13
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