Depressive Symptom Severity in Individuals with Epilepsy and Recent Health Complications

Details

• Alternative Title:
  J Nerv Ment Dis
• Personal Author:
  Kumar, Neha ; Lhatoo, Rigzin ; Liu, Hongyan ; Colon-Zimmermann, Kari ; Tatsuoka, Curtis ; Chen, Peijun ; Kahriman, Mustafa ; Sajatovic, Martha
• Description:
  Identifying relationships between depression severity and clinical factors may help with appropriate recognition and management of neuropsychiatric conditions in persons with epilepsy (PWE). Demographic characteristics, epilepsy variables, and medical and psychiatric comorbidities were examined from a baseline randomized controlled trial sample of 120 PWE. Among demographic characteristics, only inability to work was significantly associated with depression severity (p = 0.05). Higher 30-day seizure frequency (p < 0.01) and lower quality of life (p < 0.0001) were associated with greater depression severity. Comorbid bipolar disorder (p = 0.02), panic disorder (p < 0.01), and obsessive-compulsive disorder (p < 0.01) were correlated with worse depression severity. The literature supports our findings of correlations between worse depression, seizure frequency, and lower quality of life. Less well studied is our finding of greater depression severity and selected psychiatric comorbidities in PWE.
• Subjects:
  Adult Bipolar Disorder Comorbidity Depression Female Health Status Humans Male Mental Disorders Middle Aged Obsessive-Compulsive Disorder Prospective Studies Quality Of Life Severity Of Illness Index

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• Keywords:
  Bipolar Disorder Depression Epilepsy Obsessive-compulsive Disorder Panic Disorder
• Source:
  J Nerv Ment Dis. 207(4):284-290
• Pubmed ID:
  30865078
• Pubmed Central ID:
  PMC6526526
• Document Type:
  Journal Article
• Funding:
  U48 DP005030/DP/NCCDPHP CDC HHSUnited States/ ; U48DP005030/ACL/ACL HHSUnited States/ ; UL1 TR000439/TR/NCATS NIH HHSUnited States/ ; UL1 TR002548/TR/NCATS NIH HHSUnited States/
• Volume:
  207
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c6b710b2eba4be34572a04a84186163fd9c66b32ade1745ca272567482f40719
• Download URL:
  https://stacks.cdc.gov/view/cdc/78644/cdc_78644_DS1.pdf
• File Type:
  [PDF - 183.28 KB ]