In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae

Details

• Alternative Title:
  Diagn Microbiol Infect Dis
• Personal Author:
  Nash, Evelyn E. ; Henning, Tara C. ; Pham, Cau D. ; Pettus, Kevin ; Sharpe, Samera ; Kersh, Ellen N.
• Description:
  Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.
• Subjects:
  Anti-Bacterial Agents Antimicrobial Resistance Article Boric Acid Boric Acids Broth Microdilution Drug Synergism Edetic Acid EDTA Microbial Sensitivity Tests Neisseria Gonorrhoeae

  More +
• Source:
  Diagn Microbiol Infect Dis. 93(4):369-371
• Pubmed ID:
  30552033
• Pubmed Central ID:
  PMC6519449
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  93
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:595bf2c77c5ca25742da14fe601cca2babb6856b4554de86e5be2f67ebc5ad51
• Download URL:
  https://stacks.cdc.gov/view/cdc/78527/cdc_78527_DS1.pdf
• File Type:
  [PDF - 370.13 KB ]