Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Kainulainen, Markus H. ; Chakrabarti, Ayan K. ; Guerrero, Lisa W. ; Nichol, Stuart T. ; Albarino, Cesar G. ; Towner, Jonathan S.
• Description:
  Although bats are increasingly being recognized as natural reservoir hosts of emerging zoonotic viruses, little is known about how they control and clear virus infection in the absence of clinical disease. Here, we test >50 convalescent sera from Egyptian rousette bats (ERBs) experimentally primed or prime-boosted with Marburg virus, Ebola virus, or Sosuga virus for the presence of virus-specific neutralizing antibodies, using infectious reporter viruses. After serum neutralization testing, we conclude that antibody-mediated virus neutralization does not contribute significantly to the control and clearance of Marburg virus, Ebola virus, or Sosuga virus infection in ERBs.
• Subjects:
  Animals Antibodies, Viral Article Bats Chiroptera Convalescence Disease Reservoirs Ebola Virus Ebolavirus Egypt Hemorrhagic Fever, Ebola Humans Immunity, Humoral Marburg Virus Marburgvirus Marburg Virus Disease Neutralization Neutralization Tests Paramyxoviridae Sosuga Virus

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• Source:
  J Infect Dis. 219(11):1716-1721
• Pubmed ID:
  30590775
• Pubmed Central ID:
  PMC6519049
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Volume:
  219
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:cf7f1fefd3058a56b24e1bd720231bc9064181c3204df511bf7ed253e0b598ff
• Download URL:
  https://stacks.cdc.gov/view/cdc/78524/cdc_78524_DS1.pdf
• File Type:
  [PDF - 83.78 KB ]