Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats

Schuh, Amy J.; Amman, Brian R.; Sealy, Tara K.; Kainulainen, Markus H.; Chakrabarti, Ayan K.; Guerrero, Lisa W.; Nichol, Stuart T.; Albarino, Cesar G.; Towner, Jonathan S.

doi:10.1093/infdis/jiy733

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Antibody-Mediated Virus Neutralization Is Not a Universal Mechanism of Marburg, Ebola, or Sosuga Virus Clearance in Egyptian Rousette Bats

Published Date:

May 05 2019

Publisher's site:

http://dx.doi.org/10.1093/infdis/jiy733 New Site Icon

Source:

J Infect Dis. 219(11):1716-1721

Language:

English

[PDF-83.78 KB]

Details:

Personal Authors:

Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Kainulainen, Markus H. ; Chakrabarti, Ayan K. ; ... More ▼

Keywords:

[+]

Pubmed ID:

30590775

Pubmed Central ID:

PMC6519049

Description:

Although bats are increasingly being recognized as natural reservoir hosts of emerging zoonotic viruses, little is known about how they control and clear virus infection in the absence of clinical disease. Here, we test >50 convalescent sera from Egyptian rousette bats (ERBs) experimentally primed or prime-boosted with Marburg virus, Ebola virus, or Sosuga virus for the presence of virus-specific neutralizing antibodies, using infectious reporter viruses. After serum neutralization testing, we conclude that antibody-mediated virus neutralization does not contribute significantly to the control and clearance of Marburg virus, Ebola virus, or Sosuga virus infection in ERBs.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

CC999999/Intramural CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

nihms-1028160.nxml

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