Details:

Alternative Title:
J Infect Dis
Personal Author:
Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Kainulainen, Markus H. ; Chakrabarti, Ayan K. ; ... More +
Schuh, Amy J. ; Amman, Brian R. ; Sealy, Tara K. ; Kainulainen, Markus H. ; Chakrabarti, Ayan K. ; Guerrero, Lisa W. ; Nichol, Stuart T. ; Albarino, Cesar G. ; Towner, Jonathan S. Less -
Description:
Although bats are increasingly being recognized as natural reservoir hosts of emerging zoonotic viruses, little is known about how they control and clear virus infection in the absence of clinical disease. Here, we test >50 convalescent sera from Egyptian rousette bats (ERBs) experimentally primed or prime-boosted with Marburg virus, Ebola virus, or Sosuga virus for the presence of virus-specific neutralizing antibodies, using infectious reporter viruses. After serum neutralization testing, we conclude that antibody-mediated virus neutralization does not contribute significantly to the control and clearance of Marburg virus, Ebola virus, or Sosuga virus infection in ERBs.
Subject:
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Animals
Antibodies, Viral
Chiroptera
Convalescence
Disease Reservoirs
Ebolavirus
Hemorrhagic Fever, Ebola
Humans
Immunity, Humoral
Marburgvirus
Marburg Virus Disease
Neutralization Tests
Paramyxoviridae

Source:
J Infect Dis. 219(11):1716-1721
Pubmed ID:
30590775
Pubmed Central ID:
PMC6519049
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Place as Subject:
Egypt
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:cf7f1fefd3058a56b24e1bd720231bc9064181c3204df511bf7ed253e0b598ff
File Type:

Supporting Files

• nihms-1028160.nxml

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