Febrile Seizure Risk After Vaccination in Children 6 to 23 Months

Duffy, Jonathan; Weintraub, Eric; Hambidge, Simon J.; Jackson, Lisa A.; Kharbanda, Elyse O.; Klein, Nicola P.; Lee, Grace M.; Marcy, S. Michael; Nakasato, Cynthia C.; Naleway, Allison; Omer, Saad B.; Vellozzi, Claudia; DeStefano, Frank

Advanced Search

Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

Advanced Search
Custom Query

All these words:

For very narrow results

This exact word or phrase:

When looking for a specific result

Any of these words:

Best used for discovery & interchangable words

None of these words:

Recommended to be used in conjunction with other fields

Language:

Dates

Publication Date Range:

to

Document Data

Title:

Document Type:

Library

Collection:

Series:

People

Author:

Clear All

Query Builder

Query box

Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Febrile Seizure Risk After Vaccination in Children 6 to 23 Months

June 06 2016
By Duffy, Jonathan ; Weintraub, Eric ; Hambidge, Simon J. ; ...
Source: Pediatrics. 138(1)

[PDF-261.17 KB]

English

Details Supporting Files You May Also Like

Details:

Alternative Title:

Pediatrics
Personal Author:

Duffy, Jonathan ; Weintraub, Eric ; Hambidge, Simon J. ; Jackson, Lisa A. ; Kharbanda, Elyse O. ; ... More +

Duffy, Jonathan ; Weintraub, Eric ; Hambidge, Simon J. ; Jackson, Lisa A. ; Kharbanda, Elyse O. ; Klein, Nicola P. ; Lee, Grace M. ; Marcy, S. Michael ; Nakasato, Cynthia C. ; Naleway, Allison ; Omer, Saad B. ; Vellozzi, Claudia ; DeStefano, Frank Less -
Description:

BACKGROUND AND OBJECTIVE:

An increased risk of febrile seizure (FS) was identified with concomitant administration of trivalent inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) 13-valent during the 2010–2011 influenza season. Our objective was to determine whether concomitant administration of IIV3 with other vaccines affects the FS risk.

METHODS:

We examined the risk of FS 0 to 1 day postvaccination for all routinely recommended vaccines among children aged 6 through 23 months during a period encompassing 5 influenza seasons (2006–2007 through 2010–2011). We used a population-based self-controlled risk interval analysis with a control interval of 14 to 20 days postvaccination. We used multivariable regression to control for receipt of concomitant vaccines and test for interaction between vaccines.

RESULTS:

Only PCV 7-valent had an independent FS risk (incidence rate ratio [IRR], 1.98; 95% confidence interval [CI], 1.00 to 3.91). IIV3 had no independent risk (IRR, 0.46; 95% CI, 0.21 to 1.02), but risk was increased when IIV3 was given with either PCV (IRR, 3.50; 95% CI, 1.13 to 10.85) or a diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine (IRR, 3.50; 95% CI, 1.52 to 8.07). The maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines compared with administration on separate days was 30 FS per 100 000 persons vaccinated.

CONCLUSIONS:

The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day. The absolute risk of postvaccination FS with these vaccine combinations was small.
Subjects:

[+]

Article Female Humans Infant Influenza Vaccines Male Risk Assessment Seizures, Febrile Vaccination
Source:

Pediatrics. 138(1)
Pubmed ID:

27273711
Pubmed Central ID:

PMC6503849
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

138
Issue:

1
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:dde1d6430dba92b1463291aec2e994947fcdd6f904e6da6cf296f59f8ee0e222
Download URL:

https://stacks.cdc.gov/view/cdc/78364/cdc_78364_DS1.pdf
File Type:

	nihms-1021624-f0001.gif	gif
	nihms-1021624-f0001.jpg	jpeg
	nihms-1021624.nxml	xml

More +