Febrile Seizure Risk After Vaccination in Children 6 to 23 Months

Details

• Alternative Title:
  Pediatrics
• Personal Author:
  Duffy, Jonathan ; Weintraub, Eric ; Hambidge, Simon J. ; Jackson, Lisa A. ; Kharbanda, Elyse O. ; Klein, Nicola P. ; Lee, Grace M. ; Marcy, S. Michael ; Nakasato, Cynthia C. ; Naleway, Allison ; Omer, Saad B. ; Vellozzi, Claudia ; DeStefano, Frank
• Description:
  BACKGROUND AND OBJECTIVE:
  
  An increased risk of febrile seizure (FS) was identified with concomitant administration of trivalent inactivated influenza vaccine (IIV3) and pneumococcal conjugate vaccine (PCV) 13-valent during the 2010–2011 influenza season. Our objective was to determine whether concomitant administration of IIV3 with other vaccines affects the FS risk.
  
  METHODS:
  
  We examined the risk of FS 0 to 1 day postvaccination for all routinely recommended vaccines among children aged 6 through 23 months during a period encompassing 5 influenza seasons (2006–2007 through 2010–2011). We used a population-based self-controlled risk interval analysis with a control interval of 14 to 20 days postvaccination. We used multivariable regression to control for receipt of concomitant vaccines and test for interaction between vaccines.
  
  RESULTS:
  
  Only PCV 7-valent had an independent FS risk (incidence rate ratio [IRR], 1.98; 95% confidence interval [CI], 1.00 to 3.91). IIV3 had no independent risk (IRR, 0.46; 95% CI, 0.21 to 1.02), but risk was increased when IIV3 was given with either PCV (IRR, 3.50; 95% CI, 1.13 to 10.85) or a diphtheria-tetanus-acellular-pertussis (DTaP)-containing vaccine (IRR, 3.50; 95% CI, 1.52 to 8.07). The maximum estimated absolute excess risk due to concomitant administration of IIV3, PCV, and DTaP-containing vaccines compared with administration on separate days was 30 FS per 100 000 persons vaccinated.
  
  CONCLUSIONS:
  
  The administration of IIV3 on the same day as either PCV or a DTaP-containing vaccine was associated with a greater risk of FS than when IIV3 was given on a separate day. The absolute risk of postvaccination FS with these vaccine combinations was small.
  
  
• Subjects:
  Article Female Humans Infant Influenza Vaccines Male Risk Assessment Seizures, Febrile Vaccination
• Source:
  Pediatrics. 138(1)
• Pubmed ID:
  27273711
• Pubmed Central ID:
  PMC6503849
• Document Type:
  Journal Article
• Funding:
  CC999999/Intramural CDC HHS/United States
• Volume:
  138
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:dde1d6430dba92b1463291aec2e994947fcdd6f904e6da6cf296f59f8ee0e222
• Download URL:
  https://stacks.cdc.gov/view/cdc/78364/cdc_78364_DS1.pdf
• File Type:
  [PDF - 261.17 KB ]