Details:

Alternative Title:
Vaccine
Publisher's site:
http://dx.doi.org/10.1016/j.vaccine.2015.04.097
Personal Author:
Datwani, Hema ; Moro, Pedro L. ; Harrington, Theresa ; Broder, Karen
Datwani, Hema ; Moro, Pedro L. ; Harrington, Theresa ; Broder, Karen Less -
Description:
Background:

In October 2012, the Advisory Committee on Immunization Practices (ACIP) recommended a dose of tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) during each pregnancy, irrespective of the patient’s prior history of receiving Tdap. A retrospective cohort study to assess the safety of Tdap vaccination in pregnant women in two Vaccine Safety Datalink (VSD) sites during 2010-2012 found a small but statistically significant increased risk of chorioamnionitis.

Objective:

We conducted a review of the VAERS database to describe reports of chorioamnionitis following receipt of any vaccines.

Methods:

We searched the VAERS database for reports of chorioamnionitis after any vaccine in the United States during the period from July 1, 1990 through February 2, 2014.

Results:

VAERS received 31 reports of chorioamnionitis out of 3,389 pregnancy reports. The three most common vaccines administered were 2009 H1N1 inactivated influenza, quadrivalent human papillomavirus (HPV4), and Tdap vaccines in 32%, 29% and 26% of reports, respectively. Fifty-eight percent of reports had at least one risk factor for chorioamnionitis. Chorioamnionitis was identified in 3 reports of spontaneous abortions and 6 stillbirths, 6 reports of preterm birth (two of whom died) and 16 reports of term birth; maternal outcomes included two reports of postpartum hemorrhage and one report of maternal admission to the intensive care unit. No maternal deaths were reported.

Conclusion:

Chorioamnionitis was found to be uncommonly reported, representing 1% of pregnancy reports to VAERS. A majority of reports had at least one risk factor for chorioamnionitis.


Subject:
[+]
Adolescent
Adult
Adverse Drug Reaction Reporting Systems
Article
Chorioamnionitis
Diphtheria-Tetanus-acellular Pertussis Vaccines
Female
Humans
Influenza Vaccines
Papillomavirus Vaccines
Pregnancy
Retrospective Studies
Risk Factors
Vaccination
Young Adult

Source:
Vaccine. 33(27):3110-3113
Pubmed ID:
25976546
Pubmed Central ID:
PMC6500452
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:431ba784a74bb6f67be77e02f4e86bb383e7456e8b63f28f47bd3dcd41f0c1ac
File Type:

Supporting Files

• nihms-1025263.nxml

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