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Burden of respiratory abnormalities in microwave popcorn and flavouring manufacturing workers
  • Published Date:
    July 25 2018
  • Source:
    Occup Environ Med. 75(10):709-715
  • Language:
    English
Filetype[PDF-398.70 KB]


Details:
  • Alternative Title:
    Occup Environ Med
  • Description:
    Objectives

    Diacetyl, a butter-flavour compound used in food and flavouring production, is a respiratory toxin. We characterized the burden of respiratory abnormalities in workers at popcorn and flavouring manufacturing facilities that used diacetyl as evaluated through U.S. National Institute for Occupational Safety and Health (NIOSH) health hazard evaluations.

    Methods

    We performed analyses describing the number and percentage of current and former workers from popcorn and flavouring manufacturing facilities where NIOSH administered a respiratory health questionnaire and spirometry testing who met case definitions of suspected flavourings-related lung disease. Case definitions were — Pathologist-reported: lung biopsy pathology report stating supportive of/consistent with constrictive bronchiolitis or bronchiolitis obliterans; Probable: obstructive/mixed spirometric pattern with forced expiratory volume in 1 second (FEV1) <60% predicted; Possible: obstructive/mixed spirometric pattern with FEV1 ≥60% or any spirometric restriction; Symptoms Only: normal spirometry plus exertional dyspnoea or usual cough.

    Results

    During 2000–2012, NIOSH collected questionnaire and spirometry data on 1407 workers (87.0% current, 13.0% former) at nine facilities in eight states. After applying case definitions, 4 (0.3%) were classified as Pathologist-reported, 48 (3.4%) as Probable, 234 (16.6%) as Possible, and 404 (28.7%) as Symptoms Only. The remaining 717 (51.0%) workers had normal spirometry without exertional dyspnoea or usual cough. Seven of 11 workers with biopsies did not meet the Pathologist-reported case definition, although four met Probable and three met Possible.

    Conclusions

    This approach demonstrates the substantial burden of respiratory abnormalities in these workers. A similar approach could quantify the burden of respiratory abnormalities in other industries that use diacetyl.

  • Pubmed ID:
    30045951
  • Pubmed Central ID:
    PMC6482464
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