Monkeypox Transmission and Pathogenesis in Prairie Dogs

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Guarner, Jeannette ; Johnson, Bill J. ; Paddock, Christopher D. ; Shieh, Wun-Ju ; Goldsmith, Cynthia S. ; Reynolds, Mary G. ; Damon, Inger K. ; Regnery, Russell L. ; Zaki, Sherif R.
• Corporate Authors:
  Veterinary Monkeypox Virus Working Group
• Description:
  During May and June 2003, the first cluster of human monkeypox cases in the United States was reported. Most patients with this febrile vesicular rash illness presumably acquired the infection from prairie dogs. Monkeypox virus was demonstrated by using polymerase chain reaction in two prairie dogs in which pathologic studies showed necrotizing bronchopneumonia, conjunctivitis, and tongue ulceration. Immunohistochemical assays for orthopoxviruses demonstrated abundant viral antigens in surface epithelial cells of lesions in conjunctiva and tongue, with less amounts in adjacent macrophages, fibroblasts, and connective tissues. Viral antigens in the lung were abundant in bronchial epithelial cells, macrophages, and fibroblasts. Virus isolation and electron microscopy demonstrated active viral replication in lungs and tongue. These findings indicate that both respiratory and direct mucocutaneous exposures are potentially important routes of transmission of monkeypox virus between rodents and to humans. Prairie dogs offer insights into transmission, pathogenesis, and new vaccine and treatment trials because they are susceptible to severe monkeypox infection.
• Subjects:
  Animals Disease Outbreaks Humans Lung Monkeypox Virus Mpox (monkeypox) Polymorphism, Restriction Fragment Length Reverse Transcriptase Polymerase Chain Reaction Sciuridae
• Source:
  Emerg Infect Dis. 10(3):426-431
• Pubmed ID:
  15109408
• Pubmed Central ID:
  PMC3322777
• Document Type:
  Journal Article
• Volume:
  10
• Issue:
  3
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:87394904020a3e135759da7ffbdc71b091b44b8d498f677df16814e1879f5b5e
• Download URL:
  https://stacks.cdc.gov/view/cdc/7766/cdc_7766_DS1.pdf
• File Type:
  [PDF - 426.63 KB ]