Vaccinating against monkeypox in the Democratic Republic of the Congo

Petersen, Brett W.; Kabamba, Joelle; McCollum, Andrea M.; Lushima, Robert Shongo; Wemakoy, Emile Okitolonda; Tamfum, Jean-Jacques Muyembe; Nguete, Beatrice; Hughes, Christine M.; Monroe, Benjamin P.; Reynolds, Mary G.

doi:10.1016/j.antiviral.2018.11.004

i

Vaccinating against monkeypox in the Democratic Republic of the Congo

Supporting Files

2 2019
By Petersen, Brett W. ; Kabamba, Joelle ; McCollum, Andrea M. ; ...

File Language:

English

Details

Alternative Title:

Antiviral Res
Personal Author:

Petersen, Brett W. ; Kabamba, Joelle ; McCollum, Andrea M. ; Lushima, Robert Shongo ; Wemakoy, Emile Okitolonda ; Tamfum, Jean-Jacques Muyembe ; Nguete, Beatrice ; Hughes, Christine M. ; Monroe, Benjamin P. ; Reynolds, Mary G.
Description:

Healthcare-associated transmission of monkeypox has been observed on multiple occasions in areas where the disease is endemic. Data collected by the US Centers for Disease Control and Prevention (CDC) from an ongoing CDC-supported program of enhanced surveillance in the Tshuapa Province of the Democratic Republic of the Congo, where the annual incidence of human monkeypox is estimated to be 3.5-5/10,000, suggests that there is approximately one healthcare worker infection for every 100 confirmed monkeypox cases. Herein, we describe a study that commenced in February 2017, the intent of which is to evaluate the effectiveness, immunogenicity, and safety of a third-generation smallpox vaccine, IMVAMUNE|, in healthcare personnel at risk of monkeypox virus (MPXV) infection. We describe procedures for documenting exposures to monkeypox virus infection in study participants, and outline lessons learned that may be of relevance for studies of other investigational medical countermeasures in hard to reach, under-resourced populations.
Subjects:

Animals Clinical Trials As Topic Health Personnel Health Resources Humans Immunogenicity, Vaccine Monkeypox Virus Mpox (monkeypox)/prevention & Control Occupational Diseases Risk Factors Rural Population Smallpox Vaccine Vaccination Vaccines, Attenuated
Source:

Antiviral Res. 162:171-177
Pubmed ID:

30445121
Pubmed Central ID:

PMC6438175
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHSUnited States/ ; U01 CK000539/CK/NCEZID CDC HHSUnited States/
Place as Subject:

Democratic Republic of the Congo
Volume:

162
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:e7a5865c8436a307e3275e5e42814c26d278da0847cdd838882eb6b626de39b3
Download URL:

https://stacks.cdc.gov/view/cdc/77029/cdc_77029_DS1.pdf
File Type:

[PDF - 843.63 KB ]

File Language:

English

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