CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.
As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.
i
Study of selected birth defects among American Indian/Alaska Native population: A multi-state population-based retrospective study, 1999–2007
-
November 06 2018
-
-
Source: Birth Defects Res. 110(19):1412-1418
[PDF-96.49 KB]
Details:
-
Alternative Title:Birth Defects Res
-
Personal Author:
-
Corporate Authors:
-
Description:Background:
Higher prevalence of selected birth defects has been reported among American Indian/Alaska Native (AI/AN) newborns. We examine whether known risk factors for birth defects explain the higher prevalence observed for selected birth defects among this population.
Methods:
Data from 12 population-based birth defects surveillance systems, covering a birth population of 11 million from 1999 to 2007, were used to examine prevalence of birth defects that have previously been reported to have elevated prevalence among AI/ANs. Prevalence ratios (PRs) were calculated for non-Hispanic AI/ANs and any AI/ANs (regardless of Hispanic ethnicity), adjusting for maternal age, education, diabetes, and smoking, as well as type of case-finding ascertainment surveillance system.
Results:
After adjustment, the birth prevalence of two of seven birth defects remained significantly elevated among AI/ANs compared to non-Hispanic whites (NHWs): anotia/microtia was almost threefold higher, and cleft lip +/− cleft palate was almost 70% higher compared to NHWs. Excluding AI/AN subjects who were also Hispanic had only a negligible impact on adjusted PRs.
Conclusions:
Additional covariates accounted for some of the elevated birth defect prevalences among AI/ANs compared to NHWs. Exclusion of Hispanic ethnicity from the AI/AN category had little impact on birth defects prevalences in AI/ANs. NHWs serve as a viable comparison group for analysis. Birth defects among AI/ANs require additional scrutiny to identify modifiable risk and protective factors.
-
Subjects:
-
Source:
-
Pubmed ID:30403007
-
Pubmed Central ID:PMC6425493
-
Document Type:
-
Funding:
-
Place as Subject:
-
Volume:110
-
Issue:19
-
Collection(s):
-
Main Document Checksum:
-
Download URL:
-
File Type:
