Study of selected birth defects among American Indian/Alaska Native population: A multi-state population-based retrospective study, 1999–2007

Marengo, Lisa K.; Flood, Timothy J.; Ethen, Mary K.; Kirby, Russell S.; Fisher, Sarah; Copeland, Glenn; Meyer, Robert E.; Dunn, Julie; Canfield, Mark A.; Anderson, Tom; Yazzie, Del; Mai, Cara T.

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Study of selected birth defects among American Indian/Alaska Native population: A multi-state population-based retrospective study, 1999–2007

November 06 2018
By Marengo, Lisa K. ; Flood, Timothy J. ; Ethen, Mary K. ; ...
Source: Birth Defects Res. 110(19):1412-1418

[PDF-96.49 KB]

English

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Details:

Alternative Title:

Birth Defects Res
Personal Author:

Marengo, Lisa K. ; Flood, Timothy J. ; Ethen, Mary K. ; Kirby, Russell S. ; Fisher, Sarah ; ... More +

Marengo, Lisa K. ; Flood, Timothy J. ; Ethen, Mary K. ; Kirby, Russell S. ; Fisher, Sarah ; Copeland, Glenn ; Meyer, Robert E. ; Dunn, Julie ; Canfield, Mark A. ; Anderson, Tom ; Yazzie, Del ; Mai, Cara T. Less -
Corporate Authors:

National Birth Defects Prevention Network
Description:

Background:

Higher prevalence of selected birth defects has been reported among American Indian/Alaska Native (AI/AN) newborns. We examine whether known risk factors for birth defects explain the higher prevalence observed for selected birth defects among this population.

Methods:

Data from 12 population-based birth defects surveillance systems, covering a birth population of 11 million from 1999 to 2007, were used to examine prevalence of birth defects that have previously been reported to have elevated prevalence among AI/ANs. Prevalence ratios (PRs) were calculated for non-Hispanic AI/ANs and any AI/ANs (regardless of Hispanic ethnicity), adjusting for maternal age, education, diabetes, and smoking, as well as type of case-finding ascertainment surveillance system.

Results:

After adjustment, the birth prevalence of two of seven birth defects remained significantly elevated among AI/ANs compared to non-Hispanic whites (NHWs): anotia/microtia was almost threefold higher, and cleft lip +/− cleft palate was almost 70% higher compared to NHWs. Excluding AI/AN subjects who were also Hispanic had only a negligible impact on adjusted PRs.

Conclusions:

Additional covariates accounted for some of the elevated birth defect prevalences among AI/ANs compared to NHWs. Exclusion of Hispanic ethnicity from the AI/AN category had little impact on birth defects prevalences in AI/ANs. NHWs serve as a viable comparison group for analysis. Birth defects among AI/ANs require additional scrutiny to identify modifiable risk and protective factors.
Subjects:

[+]

Alaska Natives/ethnology Congenital Abnormalities/epidemiology Epidemiological Monitoring Ethnicity/genetics Female Fetus Humans Indians, North American/ethnology Infant Infant, Newborn Male Population Surveillance/methods Prevalence Public Health Retrospective Studies Risk Factors White People
Source:

Birth Defects Res. 110(19):1412-1418
Pubmed ID:

30403007
Pubmed Central ID:

PMC6425493
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Place as Subject:

United States
Volume:

110
Issue:

19
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:41556b1f8dea7de306a8dd3b0c265ca56cd87a1928cea5b4bc98db2e1850e9ef
Download URL:

https://stacks.cdc.gov/view/cdc/76976/cdc_76976_DS1.pdf
File Type:

nihms-1009662.nxml

xml

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