Details:

Alternative Title:
Birth Defects Res
Personal Author:
Marengo, Lisa K. ; Flood, Timothy J. ; Ethen, Mary K. ; Kirby, Russell S. ; Fisher, Sarah ; ... More +
Marengo, Lisa K. ; Flood, Timothy J. ; Ethen, Mary K. ; Kirby, Russell S. ; Fisher, Sarah ; Copeland, Glenn ; Meyer, Robert E. ; Dunn, Julie ; Canfield, Mark A. ; Anderson, Tom ; Yazzie, Del ; Mai, Cara T. Less -
Corporate Authors:
National Birth Defects Prevention Network
Description:
Background:

Higher prevalence of selected birth defects has been reported among American Indian/Alaska Native (AI/AN) newborns. We examine whether known risk factors for birth defects explain the higher prevalence observed for selected birth defects among this population.

Methods:

Data from 12 population-based birth defects surveillance systems, covering a birth population of 11 million from 1999 to 2007, were used to examine prevalence of birth defects that have previously been reported to have elevated prevalence among AI/ANs. Prevalence ratios (PRs) were calculated for non-Hispanic AI/ANs and any AI/ANs (regardless of Hispanic ethnicity), adjusting for maternal age, education, diabetes, and smoking, as well as type of case-finding ascertainment surveillance system.

Results:

After adjustment, the birth prevalence of two of seven birth defects remained significantly elevated among AI/ANs compared to non-Hispanic whites (NHWs): anotia/microtia was almost threefold higher, and cleft lip +/− cleft palate was almost 70% higher compared to NHWs. Excluding AI/AN subjects who were also Hispanic had only a negligible impact on adjusted PRs.

Conclusions:

Additional covariates accounted for some of the elevated birth defect prevalences among AI/ANs compared to NHWs. Exclusion of Hispanic ethnicity from the AI/AN category had little impact on birth defects prevalences in AI/ANs. NHWs serve as a viable comparison group for analysis. Birth defects among AI/ANs require additional scrutiny to identify modifiable risk and protective factors.


Subject:
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Alaska Natives/ethnology Congenital Abnormalities/epidemiology Epidemiological Monitoring Ethnicity/genetics Female Fetus Humans Indians, North American/ethnology Infant Infant, Newborn Male Population Surveillance/methods Prevalence Public Health Retrospective Studies Risk Factors Whites
Source:
Birth Defects Res. 110(19):1412-1418
Pubmed ID:
30403007
Pubmed Central ID:
PMC6425493
Document Type:
Journal Article
Funding:
CC999999/Intramural CDC HHS/United States
Place as Subject:
United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:41556b1f8dea7de306a8dd3b0c265ca56cd87a1928cea5b4bc98db2e1850e9ef
Download URL:
https://stacks.cdc.gov/view/cdc/76976/cdc_76976_DS1.pdf
File Type:

Supporting Files

• nihms-1009662.nxml

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