Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Publisher's site:
http://dx.doi.org/10.15585/mmwr.mm6809a2
Personal Author:
Mbaeyi, Chukwuma; Alleman, Mary M.; Ehrhardt, Derek; Wiesen, Eric; Burns, Cara C.; ... More +
Mbaeyi, Chukwuma; Alleman, Mary M.; Ehrhardt, Derek; Wiesen, Eric; Burns, Cara C.; Liu, Hongmei; Ewetola, Raimi; Seakamela, Lerato; Mdodo, Rennatus; Ndoutabe, Modjirom; Wenye, Pierre Kandolo; Riziki, Yogolelo; Borus, Peter; Kamugisha, Christopher; Wassilak, Steven G. F.; Less -
Description:
Widespread use of live attenuated (Sabin) oral poliovirus vaccine (OPV) has resulted in marked progress toward global poliomyelitis eradication (1). However, in underimmunized populations, extensive person-to-person transmission of Sabin poliovirus can result in genetic reversion to neurovirulence and paralytic vaccine-derived poliovirus (VDPV) disease (1). This report updates (as of February 26, 2019) previous reports on circulating VDPV type 2 (cVDPV2) outbreaks during 2017-2018 in the Democratic Republic of the Congo (DRC) and in Somalia, which experienced a concurrent cVDPV type 3 (cVDPV3) outbreak* (2,3). In DRC, 42 cases have been reported in four cVDPV2 outbreaks; paralysis onset in the most recent case was October 7, 2018 (2). Challenges to interrupting transmission have included delays in outbreak-response supplementary immunization activities (SIAs) and difficulty reaching children in all areas. In Somalia, cVDPV2 and cVDPV3 were detected in sewage before the detection of paralytic cases (3). Twelve type 2 and type 3 cVDPV cases have been confirmed; the most recent paralysis onset dates were September 2 (cVDPV2) and September 7, 2018 (cVDPV3). The primary challenge to interrupting transmission is the residence of >300,000 children in areas that are inaccessible for vaccination activities. For both countries, longer periods of surveillance are needed before interruption of cVDPV transmission can be inferred.
Subject:
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Disease Outbreaks
Full Report
Humans
Poliomyelitis
Poliovirus Vaccine, Oral

Source:
MMWR Morb Mortal Wkly Rep. 68(9):225-230;
Pubmed ID:
30845121
Pubmed Central ID:
PMC6421971
Document Type:
Journal Article;
Place as Subject:
Democratic Republic of the Congo; Somalia;
Democratic Republic of the Congo; Somalia; Less -
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:a16afedd062c05bd5488da821a3f527f2bb4a4337ad591c2f840e9b83cbd0ffe
File Type:

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