Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

Sridhar, Siddharth; Cheng, Vincent C.C.; Wong, Shuk-Ching; Yip, Cyril C.Y.; Wu, Shusheng; Lo, Anthony W.I.; Leung, Kit-Hang; Mak, Winger W.N.; Cai, Jianpiao; Li, Xin; Chan, Jasper F.W.; Lau, Susanna K.P.; Woo, Patrick C.Y.; Lai, Wai-Ming; Kwan, Tze-Hoi; Au, Timmy W.K.; Lo, Chung-Mau; Wong, Sally C.Y.; Yuen, Kwok-Yung

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Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018

Supporting Files Public Domain

Mar 2019
By Sridhar, Siddharth ; Cheng, Vincent C.C. ; Wong, Shuk-Ching ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Sridhar, Siddharth ; Cheng, Vincent C.C. ; Wong, Shuk-Ching ; Yip, Cyril C.Y. ; Wu, Shusheng ; Lo, Anthony W.I. ; Leung, Kit-Hang ; Mak, Winger W.N. ; Cai, Jianpiao ; Li, Xin ; Chan, Jasper F.W. ; Lau, Susanna K.P. ; Woo, Patrick C.Y. ; Lai, Wai-Ming ; Kwan, Tze-Hoi ; Au, Timmy W.K. ; Lo, Chung-Mau ; Wong, Sally C.Y. ; Yuen, Kwok-Yung
Description:

Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.
Subjects:

Adult Aged Child Disease Outbreaks Female Genotype* Hepatitis E/diagnosis Hepatitis E/epidemiology Hepatitis E/history Hepatitis E/virology Hepatitis E Virus History, 21st Century Humans Immunohistochemistry Male Middle Aged Molecular Typing Organ Transplantation Phylogeny Sequence Analysis, DNA Serologic Tests Synopsis Tissue Donors
Source:

Emerg Infect Dis. 25(3):425-433
Pubmed ID:

30789146
Pubmed Central ID:

PMC6390757
Document Type:

Journal Article
Place as Subject:

Hong Kong ; China
Location:

Asia
Volume:

25
Issue:

3
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:a7bdce90639df43b68156643f7bf56b0301dd055bf42c4935ef32b575f46f1b8
Download URL:

https://stacks.cdc.gov/view/cdc/76660/cdc_76660_DS1.pdf
File Type:

[PDF - 1.42 MB ]

File Language:

English

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