Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

Gubareva, Larisa V; Mishin, Vasiliy P; Patel, Mira C; Chesnokov, Anton; Nguyen, Ha T; De La Cruz, Juan; Spencer, Sarah; Campbell, Angela P; Sinner, Mallory; Reid, Heather; Garten, Rebecca; Katz, Jackie M; Fry, Alicia M; Barnes, John; Wentworth, David E

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Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons

Jan 2019
By Gubareva, Larisa V ; Mishin, Vasiliy P ; Patel, Mira C ; ...
Source: Euro Surveill. 2019; 24(3)

[PDF-142.93 KB]

English

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Details:

Alternative Title:

Euro Surveill
Personal Author:

Gubareva, Larisa V ; Mishin, Vasiliy P ; Patel, Mira C ; Chesnokov, Anton ; Nguyen, Ha T ; ... More +

Gubareva, Larisa V ; Mishin, Vasiliy P ; Patel, Mira C ; Chesnokov, Anton ; Nguyen, Ha T ; De La Cruz, Juan ; Spencer, Sarah ; Campbell, Angela P ; Sinner, Mallory ; Reid, Heather ; Garten, Rebecca ; Katz, Jackie M ; Fry, Alicia M ; Barnes, John ; Wentworth, David E Less -
Description:

The anti-influenza therapeutic baloxavir targets cap-dependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1)pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4-10-fold reduced susceptibility to baloxavir.
Subjects:

[+]

Cap-dependent Endonuclease Inhibitor Drug Resistance Influenza Influenza Surveillance Next Generation Sequencing Phenotypic Testing Polymerase Acidic Protein Rapid Communication
Source:

Euro Surveill. 2019; 24(3)
Pubmed ID:

30670144
Pubmed Central ID:

PMC6344838
Document Type:

Journal Article
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:fa2b24ed2a253dec7441247b0d063a89915edfa377dd722ceeaa7dd02c98207f
Download URL:

https://stacks.cdc.gov/view/cdc/76161/cdc_76161_DS1.pdf
File Type:

	1800666_GUBAREVA_Supplementary.pdf	pdf
	eurosurv-24-3-3.nxml	xml

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