Details:

Alternative Title:
Arthritis Care Res (Hoboken)
Personal Author:
Barbour, Kamil E. ; Sagawa, Naoko ; Boudreau, Robert M. ; Winger, Mary E. ; Cauley, Jane A. ; ... More +
Barbour, Kamil E. ; Sagawa, Naoko ; Boudreau, Robert M. ; Winger, Mary E. ; Cauley, Jane A. ; Nevitt, Michael C. ; Fujii, Tomoko ; Patel, Kushang V. ; Strotmeyer, Elsa S. Less -
Description:
Background:

The risk of falls among adults with knee osteoarthritis (OA) has been documented, yet, to our knowledge no studies have examined knee OA and medically treated injurious falls (hereafter injurious falls) (overall and by sex), an outcome of substantial clinical and public health relevance.

Methods:

Using data from the Health ABC Knee Osteoarthritis Substudy, a community-based study of white and black older adults, we tested associations between knee OA status and the risk of injurious falls among 734 participants with a mean (SD) age of 74.7 (2.9) years. Knee radiographic osteoarthritis (ROA) was defined as having a Kellgren-Lawrence grade of ≥2 in at least one knee. Knee symptomatic ROA (sROA) was defined as having both ROA and pain symptoms in the same knee. Injurious falls were defined using a validated diagnoses code algorithm from linked Medicare Fee-for-Service claims. Cox regression modeling was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

Results:

The mean (SD) follow-up time was 6.59 (3.12) years. Of the 734 participants, 255 (34.7%) had an incident injurious fall over the entire study period. In the multivariate model, compared with those without ROA or pain, individuals with sROA (HR=1.09; 95% CI: 0.73, 1.65) did not have a significantly increased risk of injurious falls. Compared with men without ROA or pain, men with sROA (HR=2.57; 95% CI: 1.12, 5.91) had a significantly higher risk of injurious falls. No associations were found for women or by injurious fall type.

Conclusion:

Knee sROA was independently associated with an increased risk of injurious falls in older men, but not in older women.


Subject:
[+]
Accidental Falls
Aged
Female
Humans
Knee Joint
Male
Osteoarthritis, Knee
Prevalence
Prognosis
Risk Assessment
Risk Factors
Sex Factors
Tennessee
Time Factors

Source:
Arthritis Care Res (Hoboken). 71(7):865-874
Pubmed ID:
30133173
Pubmed Central ID:
PMC6384154
Document Type:
Journal Article
Funding:
P30 AG024827/AG/NIA NIH HHS/United States ; N01 AG062101/AG/NIA NIH HHS/United States ; N01 AG062106/AG/NIA NIH HHS/United States ; R01 NR012459/NR/NINR NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; ... More +
P30 AG024827/AG/NIA NIH HHS/United States ; N01 AG062101/AG/NIA NIH HHS/United States ; N01 AG062106/AG/NIA NIH HHS/United States ; R01 NR012459/NR/NINR NIH HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; NIH (Intramural Research Program)/International ; R01 AG028050/AG/NIA NIH HHS/United States ; T32 AG000181/AG/NIA NIH HHS/United States ; N01 AG062103/AG/NIA NIH HHS/United States Less -
Place as Subject:
Pennsylvania
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:59e91b2983676d95b6da3189bc69ecfc32b7461cecb79d604e237e2dc492e7d5
File Type:

Supporting Files

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