Characteristics of Deceased Solid Organ Donors and Screening Results for Hepatitis B, C, and Human Immunodeficiency Viruses — United States, 2010–2017

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Abara, Winston E. ; Collier, Melissa G. ; Moorman, Anne ; Bixler, Danae ; Jones, Jefferson ; Annambhotla, Pallavi ; Bowman, James ; Levi, Marilyn E. ; Brooks, John T. ; Basavaraju, Sridhar V.
• Corporate Authors:
  National Center for HIV, Viral Hepatitis, STD, and TB Prevention (U.S.)Division of Viral Hepatitis. ; National Center for Emerging and Zoonotic Infectious Diseases (U.S.)Division of Healthcare Quality Promotion. ; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB (U.S.)Division of HIV/AIDS Prevention.
• Description:
  The ongoing U.S. opioid crisis has resulted in an increase in drug overdose deaths and acute hepatitis C Virus (HCV) infections, with young persons (who might be eligible organ donors) most affected.*| In 2013, the Public Health Service released a revised guideline to reduce the risk for unintended organ transplantation-associated hepatitis B Virus (HBV), HCV, and human immunodeficiency Virus (HIV) Transmission (1). The guideline describes criteria to categorize donors at increased risk (increased risk donors [IRDs]) for transmitting these Viruses to recipients (1). It also recommends universal donor tTesting for HBV, HCV, and HIV.| CDC analyzed deceased donor data for the period 2010-2017 reported to the Organ Procurement and Transplantation Network for IRDs and standard risk donors (SRDs) (i.e., donors who do not meet any of the criteria for increased risk designation). During this period, the proportion of IRDs increased approximately 200%, from 8.9% to 26.3%; the percentage with drug intoxication reported as the mechanism of death also increased approximately 200%, from 4.3% to 13.4%; and the proportion of these donors with reported injection drug use (IDU) increased approximately 500%, from 1.3% to 8.0%. Compared with SRDs, IRDs were significantly more likely to have positive HBV and HCV screening results. These findings demonstrate the continuing need for identifying viral bloodborne pathogen infection risk factors among deceased donors to reduce the risk for Transmission, monitor posttransplant infection in recipients, and offer treatment if infection occurs.
• Subjects:
  Adolescent Adult Aged Cadaver Child Child, Preschool Female Full Report HepaciVirus Hepatitis B Virus HIV Humans Infant Infant, Newborn Male Mass Screening Middle Aged Risk Tissue Donors Young Adult

  More +
• Source:
  MMWR Morbidity Mortal Weekly Rep. 68(3):61-66
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6803a2
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  30677008
• Pubmed Central ID:
  PMC6348762
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Pages in Document:
  6 pdf pages
• Volume:
  68
• Issue:
  3
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:a705a09f6b076376d1ce9f897232b03c7ca05f56d47973970ba752713a4d98934de5e6f78dc47b033abe90a58db918cf9f8769453ef0799720f3bf89d1e9ebb7
• Download URL:
  https://stacks.cdc.gov/view/cdc/76013/cdc_76013_DS1.pdf
• File Type:
  [PDF - 129.75 KB ]