Details:

Alternative Title:
J Acquir Immune Defic Syndr
Personal Author:
Halec, Gordana ; Waterboer, Tim ; Brenner, Nicole ; Butt, Julia ; Hardy, David W. ; ... More +
Halec, Gordana ; Waterboer, Tim ; Brenner, Nicole ; Butt, Julia ; Hardy, David W. ; D’Souza, Gypsyamber ; Wolinsky, Steven ; Macatangay, Bernard J. ; Pawlita, Michael ; Detels, Roger ; Martínez-Maza, Otoniel ; Hussain, Shehnaz K. Less -
Description:
Background:

HIV infection is associated with increased susceptibility to common pathogens which may trigger chronic antigenic stimulation and hyperactivation of B-cells, events known to precede the development of AIDS-associated non-Hodgkin lymphoma (AIDS-NHL).

Methods:

To explore whether cumulative exposure to infectious agents contributes to AIDS-NHL risk, we tested sera from 199 AIDS-NHL patients (pre-NHL, average lead-time 3.9 years) and 199 matched HIV-infected controls from the Multicenter AIDS Cohort Study (MACS), for anti-IgG responses to 18 pathogens using multiplex serology. Odds ratios and 95% confidence intervals were estimated using conditional logistic regression models.

Results:

We found no association between cumulative exposure to infectious agents and AIDS-NHL risk (OR 1.01, 95% CI 0.91–1.12). However, seropositivity for trichodysplasia spinulosa polyomavirus (TSPyV), defined as presence of antibodies to TSPyV capsid protein VP1, was significantly associated with a 1.6-fold increase in AIDS-NHL risk (OR 1.62, 95% CI 1.02–2.57). High Epstein-Barr virus (EBV) anti-VCA p18 antibody levels closer to the time of AIDS-NHL diagnosis (<4 years) were associated with a 2.6-fold increase in AIDS-NHL risk (OR 2.59, 95% CI 1.17–5.74). Additionally, high EBV anti-EBNA-1 and anti-ZEBRA antibody levels were associated with 2.1-fold (OR 0.47, 95% CI 0.26–0.85) and 1.6-fold (OR 0.57, 95% CI 0.35–0.93) decreased risk for AIDS-NHL, respectively.

Conclusions:

Our results do not support the hypothesis that cumulative exposure to infectious agents contributes to AIDS-NHL development. However, the observed associations with respect to TSPyV seropositivity and EBV antigen antibody levels offer additional insights into the pathogenesis of AIDS-NHL.


Subjects:
[+]
Acquired Immunodeficiency Syndrome AIDS-NHL AIDS-Related Opportunistic Infections Antibodies Article Communicable Diseases HIV Humans Infections Lymphoma, Non-Hodgkin Multiplex Serology Risk Factors
Source:
J Acquir Immune Defic Syndr. 80(3):e53-e63
Pubmed ID:
30531297
Pubmed Central ID:
PMC6375787
Document Type:
Journal Article
Funding:
U01 AI035042/AI/NIAID NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; UL1 TR001079/TR/NCATS NIH HHSUnited States/ ; R01 CA168482/CA/NCI NIH HHSUnited States/ ; U01 AI035041/AI/NIAID NIH HHSUnited States/ ; ... More +
U01 AI035042/AI/NIAID NIH HHSUnited States/ ; HHSN261201000140C/CA/NCI NIH HHSUnited States/ ; UL1 TR001079/TR/NCATS NIH HHSUnited States/ ; R01 CA168482/CA/NCI NIH HHSUnited States/ ; U01 AI035041/AI/NIAID NIH HHSUnited States/ ; U58 DP000795/DP/NCCDPHP CDC HHSUnited States/ ; U01 HL146201/HL/NHLBI NIH HHSUnited States/ ; HHSN261201000035I/CA/NCI NIH HHSUnited States/ ; U58 DP003862/DP/NCCDPHP CDC HHSUnited States/ ; U01 AI035040/AI/NIAID NIH HHSUnited States/ ; U01 AI035039/AI/NIAID NIH HHSUnited States/ ; P30 MH058107/MH/NIMH NIH HHSUnited States/ ; UM1 AI035043/AI/NIAID NIH HHSUnited States/ ; HHSN261201000035C/PC/NCI NIH HHSUnited States/ ; HHSN261201000034C/CA/NCI NIH HHSUnited States/ Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:65077c8ac3774ffe47c633948127a3fdfeb29ff350ec43409f306fe94da3902f
Download URL:
https://stacks.cdc.gov/view/cdc/75984/cdc_75984_DS1.pdf
File Type:

Supporting Files

• 	nihms-1511780.nxml	xml
  	NIHMS1511780-supplement-Supplemental_Digital_Content.doc	doc

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