Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015

Details

• Journal Article:
  Open Forum Infect Dis
• Personal Author:
  Sawadogo, Souleymane ; Shiningavamwe, Andreas ; Roscoe, Clay ; Baughman, Andrew L ; Negussie, Taffa ; Mutandi, Gram ; Yang, Chunfu ; Hamunime, Ndapewa ; Agolory, Simon
• Description:
  Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.
• Subjects:
  Anti-HIV Agents/pharmacology Drug Resistance, Viral HIV Infection/ Drug Therapy
• Source:
  Open Forum Infect Dis. 2018; 5(2)
• DOI:
  http://dx.doi.org/10.1093/ofid/ofy014
• Pubmed ID:
  30568984
• Pubmed Central ID:
  PMC5798139
• Document Type:
  Text ; Journal Article
• Genre:
  Journal Article
• Place as Subject:
  Namibia
• Volume:
  5
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:5123d2db36bd89f37462837596a1c3c4c80387b9bcfc2403ddee384b43d3b0765628664d2f0563880bc8dccfaa6d3d86794a215938431f51e4cc2782d41184e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/75968/cdc_75968_DS1.pdf
• File Type:
  [PDF - 135.25 KB ]