Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015

Details

• Alternative Title:
  Open Forum Infect Dis
• Personal Author:
  Sawadogo, Souleymane ; Shiningavamwe, Andreas ; Roscoe, Clay ; Baughman, Andrew L ; Negussie, Taffa ; Mutandi, Gram ; Yang, Chunfu ; Hamunime, Ndapewa ; Agolory, Simon
• Description:
  Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.
• Subjects:
  Anti-HIV Agents/pharmacology Drug Resistance, Viral HIV Infection/ Drug Therapy
• Source:
  Open Forum Infect Dis. 2018; 5(2)
• Pubmed ID:
  30568984
• Pubmed Central ID:
  PMC5798139
• Document Type:
  Journal Article
• Place as Subject:
  Namibia
• Volume:
  5
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:94f6a58c463f470ea231f7ca252a18af95a244f9591f9ad6d371728c85e0f956
• Download URL:
  https://stacks.cdc.gov/view/cdc/75968/cdc_75968_DS1.pdf
• File Type:
  [PDF - 135.25 KB ]