Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015

Sawadogo, Souleymane; Shiningavamwe, Andreas; Roscoe, Clay; Baughman, Andrew L; Negussie, Taffa; Mutandi, Gram; Yang, Chunfu; Hamunime, Ndapewa; Agolory, Simon

doi:10.1093/ofid/ofy014

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Human Immunodeficiency Virus-1 Drug Resistance Patterns Among Adult Patients Failing Second-Line Protease Inhibitor-Containing Regimens in Namibia, 2010–2015

Jan 12 2018
By Sawadogo, Souleymane ; Shiningavamwe, Andreas ; Roscoe, Clay ; ...
http://dx.doi.org/10.1093/ofid/ofy014
Source: Open Forum Infect Dis. 2018; 5(2)

[PDF-135.25 KB]

English

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Details:

Alternative Title:

Open Forum Infect Dis
Personal Author:

Sawadogo, Souleymane ; Shiningavamwe, Andreas ; Roscoe, Clay ; Baughman, Andrew L ; Negussie, Taffa ; ... More +

Sawadogo, Souleymane ; Shiningavamwe, Andreas ; Roscoe, Clay ; Baughman, Andrew L ; Negussie, Taffa ; Mutandi, Gram ; Yang, Chunfu ; Hamunime, Ndapewa ; Agolory, Simon Less -
Description:

Three hundred sixty-six adult patients in Namibia with second-line virologic failures were evaluated for human immunodeficiency virus drug-resistant (HIVDR) mutations. Less than half (41.5%) harbored ≥1 HIVDR mutations to standardized second-line antiretroviral therapy (ART) regimen. Optimizing adherence, viral load monitoring, and genotyping are critical to prevent emergence of resistance, as well as unnecessary switching to costly third-line ART regimens.
Subjects:

[+]

Anti-HIV Agents/pharmacology Drug Resistance, Viral HIV Infection/ Drug Therapy
Source:

Open Forum Infect Dis. 2018; 5(2)
Pubmed ID:

30568984
Pubmed Central ID:

PMC5798139
Document Type:

Journal Article
Place as Subject:

Namibia
Collection(s):

CDC Public Access
Main Document Checksum:

[+]

urn:sha256:94f6a58c463f470ea231f7ca252a18af95a244f9591f9ad6d371728c85e0f956
Download URL:

https://stacks.cdc.gov/view/cdc/75968/cdc_75968_DS1.pdf
File Type:

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