The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop

Details

• Alternative Title:
  Genetics in medicine : official journal of the American College of Medical Genetics
• Corporate Authors:
  United States. National Institutes of Health. ; Centers for Disease Control and Prevention (U.S.). Office of Public Health Genomics.
• Description:
  The increasing availability of personal genomic tests has led to discussions about the validity and utility of such tests and the balance of benefits and harms. A multidisciplinary workshop was convened by the National Institutes of Health and the Centers for Disease Control and Prevention to review the scientific foundation for using personal genomics in risk assessment and disease prevention and to develop recommendations for targeted research. The clinical validity and utility of personal genomics is a moving target with rapidly developing discoveries but little translation research to close the gap between discoveries and health impact. Workshop participants made recommendations in five domains: (1) developing and applying scientific standards for assessing personal genomic tests; (2) developing and applying a multidisciplinary research agenda, including observational studies and clinical trials to fill knowledge gaps in clinical validity and utility; (3) enhancing credible knowledge synthesis and information dissemination to clinicians and consumers; (4) linking scientific findings to evidence-based recommendations for use of personal genomics; and (5) assessing how the concept of personal utility can affect health benefits, costs, and risks by developing appropriate metrics for evaluation. To fulfill the promise of personal genomics, a rigorous multidisciplinary research agenda is needed.
• Subjects:
  Genomics Humans Information Dissemination Personal Health Services
• Source:
  Genetics in medicine : official journal of the American College of Medical Genetics. 2009; 11(8):559-67.
• Pubmed ID:
  9617843
• Document Type:
  Journal Article
• Genre:
  Conference Publications
• Place as Subject:
  United States
• Volume:
  11
• Issue:
  8
• Collection(s):
  Guidelines and Recommendations
• Main Document Checksum:
  urn:sha-512:ec554c8812935840c4a123a530edf6980622595c1639c0ec85b9b5e691601ad3cc223e3b6c841875c97fdbd7ec0bb78b32135c94d3f38893aa8c11a9320a7ef0
• Download URL:
  https://stacks.cdc.gov/view/cdc/7557/cdc_7557_DS1.pdf
• File Type:
  [PDF - 86.16 KB ]