Welcome to CDC Stacks | STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement - 7556 | Guidelines and Recommendations
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
 
 
Help
Clear All Simple Search
Advanced Search
STrengthening the REporting of Genetic Association studies (STREGA): an extension of the STROBE Statement
  • Status:
    current
  • Source:
    Annals of internal medicine. 2009; 150(3):206-15.
Filetype[PDF - 86.16 KB]


Details:
  • Corporate Authors:
    Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. mkhoury@cdc.gov
  • Description:
    Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information into the practice of medicine and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the STrengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and issues of data volume that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.

  • Supporting Files:
    No Additional Files