Association of Germline Genetic Test Type and Results With Patient Cancer Worry After Diagnosis of Breast Cancer

Katz, Steven J.; Ward, Kevin C.; Hamilton, Ann S.; Abrahamse, Paul; Hawley, Sarah T.; Kurian, Allison W.

doi:10.1200/PO.18.00225

Back to Previous Page

- Add this to...
- Twitter
- Facebook
- Google Bookmarks
- LinkedIn

Association of Germline Genetic Test Type and Results With Patient Cancer Worry After Diagnosis of Breast Cancer

Published Date:

Dec 19 2018

Publisher's site:

http://dx.doi.org/10.1200/PO.18.00225 New Site Icon

Source:

JCO Precis Oncol. 2018

Language:

English

[PDF-500.25 KB]

Details:

Personal Authors:

Katz, Steven J. ; Ward, Kevin C. ; Hamilton, Ann S. ; Abrahamse, Paul ; Hawley, Sarah T. ; ... More ▼

Keywords:

[+]

Pubmed ID:

30656245

Pubmed Central ID:

PMC6333469

Description:

Background

There are concerns that multigene panel testing compared with BRCA1/ 2-only testing after diagnosis of breast cancer may lead to unnecessary patient worry about cancer because of more ambiguous results.

Methods

Patients with breast cancer diagnosed from 2013 to 2015 and accrued from SEER registries in Georgia and Los Angeles were surveyed (n = 5,080; response rate, 70%), and responses were merged with SEER data and germline genetic testing and results. We examined patient reports of cancer worry by test type and results in 1,063 women who linked to a genetic test and reported undergoing testing.

Results

More than half of the sample (n = 640; 60.2%) received BRCA1/2-only testing versus 423 patients (39.8%) who had a multigene panel. A minority of tested patients reported substantial cancer worry after treatment: 11.1% (n = 130) reported higher impact of cancer worry, and 15.1% (n = 162) reported a high frequency of cancer worry (worrying often or almost always) in the past month. Impact of cancer worry did not substantively differ by test type, test result outcomes, or clinical or treatment factors. The odds ratio for higher impact of cancer worry was 0.81 (95% CI, 0.51 to 1.28) for multigene versus BRCA1/2-only testing. In a separate model, the odds ratios were 1.21 (95% CI, 0.54 to 2.68) and 0.90 (95% CI, 0.50 to 1.62) for pathogenic variant and variant of uncertain significance, respectively, versus a negative test (the reference group).

Conclusion

Compared with BRCA1/2 testing alone, multigene panel testing was not associated with increased cancer worry after diagnosis of breast cancer.

Document Type:

Journal Article

Collection(s):

CDC Public Access

Funding:

HHSN261201000140C/CA/NCI NIH HHS/United States
HHSN261201000035C/CA/NCI NIH HHS/United States
P30 CA046592/CA/NCI NIH HHS/United States
P01 CA163233/CA/NCI NIH HHS/United States
U58 DP003875/DP/NCCDPHP CDC HHS/United States
HHSN261201300015C/RC/CCR NIH HHS/United States
HHSN261201000035I/CA/NCI NIH HHS/United States
HHSN261201000034C/CA/NCI NIH HHS/United States
U58 DP003862/DP/NCCDPHP CDC HHS/United States

Main Document Checksum:

[+]

Supporting Files:

	nihms-1004668-f0001.gif	image/gif
	nihms-1004668-f0001.jpg	image/jpeg
	nihms-1004668-f0002.gif	image/gif
	nihms-1004668-f0002.jpg	image/jpeg
	nihms-1004668.nxml	text/xml

No Related Documents.

You May Also Like:

Second Opinions from Medical Oncologists for Early-Stage Breast Cancer: Prevalence, Correlates and Consequences

Personal Author:

Kurian, Allison W.; Friese, Christopher R.; Bondarenko, Irina; Jagsi, Reshma; Li, Yun; Hamilton, Ann S.; Ward, Kevin C.; Katz, Steven J.;

Published:

Mar 01 2017

Source:

JAMA Oncol. 3(3):391-397.

Description:

Importance : Advances in the evaluation and treatment of breast cancer have made the clinical decision-making context much more complex. A second medical oncology opinion may facilitate decision-making for women with breast cancer, yet little is know...

File Type:

[PDF - 565.83 KB]
Risk of extracolonic cancers for people with biallelic and monoallelic mutations in MUTYH

Personal Author:

Win, Aung Ko; Reece, Jeanette C.; Dowty, James G.; Buchanan, Daniel D.; Clendenning, Mark; Rosty, Christophe; Southey, Melissa C.; Young, Joanne P.; Cleary, Sean P.; Kim, Hyeja; Cotterchio, Michelle; Macrae, Finlay A.; Tucker, Katherine M.; Baron, John A.; Burnett, Terrilea; Le Marchand, Loïc; Casey, Graham; Haile, Robert W.; Newcomb, Polly A.; Thibodeau, Stephen N.; Hopper, John L.; Gallinger, Steven; Winship, Ingrid M.; Lindor, Noralane M.; Jenkins, Mark A.;

Published:

Jun 02 2016

Source:

Int J Cancer. 139(7):1557-1563.

Description:

Germline mutations in the DNA base excision repair gene MUTYH are known to increase a carrier's risk of colorectal cancer. However, the risks of other (extracolonic) cancers for MUTYH mutation carriers are not well defined. We identified 266 probands...

File Type:

[PDF - 235.11 KB]
CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women

Personal Author:

Azrak, Sami; Ayyasamy, Vanniarajan; Zirpoli, Gary; Ambrosone, Christine; Bandera, Elisa V.; Bovbjerg, Dana H.; Jandorf, Lina; Ciupak, Gregory; Davis, Warren; Pawlish, Karen S.; Liang, Ping; Singh, Keshav;

Published:

Jan 20 2012

Source:

PLoS One. 2012; 7(1).

Description:

The DNA polymerase-gamma (POLG) gene, which encodes the catalytic subunit of enzyme responsible for directing mitochondrial DNA replication in humans, contains a polyglutamine tract encoded by CAG repeats of varying length. The length of the CAG repe...

File Type:

[PDF - 151.27 KB]
Higher Absolute Lymphocyte Counts Predict Lower Mortality from Early-Stage Triple-Negative Breast Cancer

Personal Author:

Afghahi, Anosheh; Purington, Natasha; Han, Summer S.; Desai, Manisha; Pierson, Emma; Mathur, Maya B.; Seto, Tina; Thompson, Caroline A.; Rigdon, Joseph; Telli, Melinda L.; Badve, Sunil S.; Curtis, Christina N.; West, Robert B.; Horst, Kathleen; Gomez, Scarlett L.; Ford, James M.; Sledge, George W.; Kurian, Allison W.;

Published:

March 26 2018

Source:

Clin Cancer Res. 24(12):2851-2858

Description:

Purpose: : Tumor-infiltrating lymphocytes (TIL) in pretreatment biopsies are associated with improved survival in triple-negative breast cancer (TNBC). We investigated whether higher peripheral lymphocyte counts are associated with lower breast cance...

File Type:

[PDF - 522.05 KB]
The association of copy number variation and percent mammographic density

Personal Author:

Atkinson, Elizabeth J; Eckel-Passow, Jeanette E; Wang, Alice; Greenberg, Alexandra J; Scott, Christopher G; Pankratz, V Shane; Purrington, Kristen N; Sellers, Thomas A; Rider, David N; Heit, John A; de Andrade, Mariza; Cunningham, Julie M; Couch, Fergus J; Vachon, Celine M;

Published:

Jul 08 2015

Source:

BMC Res Notes. 8.

Description:

Background : Percent mammographic density (PD) estimates the proportion of stromal, fat, and epithelial breast tissues on the mammogram image. Adjusted for age and body mass index (BMI), PD is one of the strongest risk factors for breast cancer [1]. ...

File Type:

[PDF - 1.51 MB]