2018-2019 Influenza Season Week 4 ending January 26, 2019
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    All data are preliminary and may change as more reports are received.

    An overview of the CDC influenza surveillance system, including methodology and detailed descriptions of each data component, is available at http://www.cdc.gov/flu/weekly/overview.htm.

    Synopsis: Influenza activity increased in the United States. Influenza A(H1N1)pdm09, influenza A(H3N2), and influenza B viruses continue to co-circulate. Below is a summary of the key influenza indicators for the week ending January 26, 2019:

    • Viral Surveillance: The percentage of respiratory specimens testing positive for influenza viruses in clinical laboratories increased. Influenza A viruses have predominated in the United States since the beginning of October. Influenza A(H1N1)pdm09 viruses have predominated in most areas of the country, however influenza A(H3) viruses have predominated in the southeastern United States (HHS Region 4).

    o Virus Characterization: The majority of influenza viruses characterized antigenically and genetically are similar to the cell-grown reference viruses representing the 2018–2019 Northern Hemisphere influenza vaccine viruses.

    o Antiviral Resistance:The vast majority of influenza viruses tested (>99%) show susceptibility to oseltamivir and peramivir. All influenza viruses tested showed susceptibility to zanamivir.

    • Influenza-like Illness Surveillance:The proportion of outpatient visits for influenza-like illness (ILI) increased to 3.8%, which is above the national baseline of 2.2%. All 10 regions reported ILI at or above their region-specific baseline level.

    o ILI State Activity Indictor Map: New York City and 23 states experienced high ILI activity; Puerto Rico and 10 states experienced moderate ILI activity; the District of Columbia and 13 states experienced low ILI activity; and four states experienced minimal ILI activity.

    • Geographic Spread of Influenza: The geographic spread of influenza in 45 states was reported as widespread; Puerto Rico and three states reported regional activity; two states reported local activity; the District of Columbia and the U.S. Virgin Islands reported sporadic activity; and Guam did not report.

    • Influenza-associated Hospitalizations A cumulative rate of 15.3 laboratory-confirmed influenza-associated hospitalizations per 100,000 population was reported. The highest hospitalization rate is among adults 65 years and older (39.8 hospitalizations per 100,000 population).

    • Pneumonia and Influenza Mortality: The proportion of deaths attributed to pneumonia and influenza (P&I) was at the system-specific epidemic threshold in the National Center for Health Statistics (NCHS) Mortality Surveillance System.

    • Influenza-associated Pediatric Deaths: Two influenza-associated pediatric deaths were reported to CDC during week 4.

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