Relationship of Weight Outcomes, Co-Occurring Conditions, and Severity of Autism Spectrum Disorder in the Study to Explore Early Development

Details

• Alternative Title:
  J Pediatr
• Personal Author:
  Levy, Susan E. ; Pinto-Martin, Jennifer A. ; Bradley, Chyrise B. ; Chittams, Jesse ; Johnson, Susan L. ; Pandey, Juhi ; Pomykacz, Alison ; Ramirez, AnnJosette ; Reynolds, Ann ; Rubenstein, Eric ; Schieve, Laura A. ; Shapira, Stuart K. ; Thompson, Aleda ; Young, Lisa ; Kral, Tanja V. E.
• Description:
  Objective
  
  To assess contributing factors to increased obesity risk, by comparing children with autism spectrum disorder (ASD), developmental delays/disorders, and general population controls in weight status, and to examine associations between weight status and presence of co-occurring medical, behavioral, developmental, or psychiatric conditions across groups and ASD severity among children with ASD.
  
  Study design
  
  The Study to Explore Early Development is a multisite cross-sectional study of children, 2–5 years of age, classified as children with ASD (n = 668), children with developmental delays/disorders (n = 914), or general population controls (n = 884). Using an observational cohort design, we compared the 3 groups. Children’s heights and weights were measured during a clinical visit. Co-occurring conditions (medical, behavioral, developmental/psychiatric) were derived from medical records, interviews, and questionnaires. ASD severity was measured by the Ohio State University Global Severity Scale for Autism.
  
  Results
  
  The odds of overweight/obesity were 1.57 times (95% CI 1.24–2.00) higher in children with ASD than general population controls and 1.38 times (95% CI 1.10–1.72) higher in children with developmental delays/disorders than general population controls. The aORs were elevated for children with ASD after controlling for child co-occurring conditions (ASD vs general population controls: aOR = 1.51; 95% CI 1.14–2.00). Among children with ASD, those with severe ASD symptoms were 1.7 times (95% CI 1.1–2.8) more likely to be classified as overweight/obese compared with children with mild ASD symptoms.
  
  Conclusions
  
  Prevention of excess weight gain in children with ASD, especially those with severe symptoms, and in children with developmental delays/disorders represents an important target for intervention.
  
  
• Subjects:
  Autism Spectrum Disorder Body Weight Child, Preschool Child Development Child Development Disorders, Pervasive Comorbidity Cross-Sectional Studies Female Follow-Up Studies Humans Male Population Surveillance Prevalence Retrospective Studies Severity Of Illness Index

  More +
• Source:
  J Pediatr. 205:202-209
• Pubmed ID:
  30314662
• Pubmed Central ID:
  PMC6348122
• Document Type:
  Journal Article
• Funding:
  U10 DD000180/DD/NCBDD CDC HHS/United States ; U10 DD000181/DD/NCBDD CDC HHS/United States ; U10 DD000184/DD/NCBDD CDC HHS/United States ; U01 DD001210/DD/NCBDD CDC HHS/United States ; U01 DD000498/DD/NCBDD CDC HHS/United States ; CC999999/ImCDC/Intramural CDC HHS/United States ; U10 DD000182/DD/NCBDD CDC HHS/United States ; U10 DD000183/DD/NCBDD CDC HHS/United States
• Place as Subject:
  United States
• Volume:
  205
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:d8380022325b1fdabfee2194806566d86327de2126002b1c672350475b424a19
• Download URL:
  https://stacks.cdc.gov/view/cdc/75350/cdc_75350_DS1.pdf
• File Type:
  [PDF - 410.57 KB ]