Recommendations for Use of a Booster Dose of Inactivated Vero Cell Culture-Derived Japanese Encephalitis Vaccine—Advisory Committee on Immunization Practices, 2011

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Corporate Authors:
  National Center for Zoonotic, Vector-Borne and Enteric Diseases (U.S.). Division of Vector Borne Infectious Diseases. ; United States. Advisory Committee on Immunization Practices.
• Description:
  Japanese encephalitis (JE) virus, a mosquito-borne flavivirus, is an important cause of encephalitis in Asia with a case fatality rate of 20%--30% and neurologic or psychiatric sequelae in 30%--50% of survivors (1). Travelers to JE-endemic countries and laboratory personnel who work with infectious JE virus are at potential risk for JE virus infection. In 2010, CDC's Advisory Committee on Immunization Practices (ACIP) updated recommendations for prevention of JE. The updated recommendations included information on use of a new inactivated, Vero cell culture--derived JE vaccine (JE-VC [manufactured as Ixiaro]) that was licensed in the United States in 2009. Data on the need for and timing of booster doses with JE-VC were not available when the vaccine was licensed. This report summarizes new data on the persistence of neutralizing antibodies following primary vaccination with JE-VC and the safety and immunogenicity of a booster dose of JE-VC. The report also provides updated guidance to health-care personnel regarding use of a booster dose of JE-VC for U.S. travelers and laboratory personnel. ACIP recommends that if the primary series of JE-VC was administered >1 year previously, a booster dose may be given before potential JE virus exposure.
• Subjects:
  Adolescent Adult Aged Animals Antibodies, Neutralizing Cercopithecus Aethiops Clinical Trials As Topic Encephalitis, Japanese Encephalitis Viruses, Japanese Guidelines As Topic Health Personnel Humans Immunization, Secondary Japanese Encephalitis Vaccines Laboratories Middle Aged Vaccines, Inactivated Vero Cells

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• Source:
  MMWR. Morbidity and mortality weekly report. 2011; 60(20):661-3.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  21617632
• Document Type:
  Journal Article
• Name as Subject:
  Centers for Disease Control and Prevention (U.S.) ; Centers for Disease Control and Prevention (U.S.)
• Place as Subject:
  Asia ; United States
• Pages in Document:
  3 pdf pages
• Volume:
  60
• Issue:
  20
• Collection(s):
  Guidelines and Recommendations Morbidity and Mortality Weekly Report (MMWR) Advisory Committee on Immunization Practices (ACIP)
• Main Document Checksum:
  urn:sha-512:57e701b94d2d124967bfaf126967523a386f3af5cecc087d648fa6d3d6f9119d4e899bfe11066d00c13e815997844af779d970c5cc489bf9fbc0167d21241742
• Download URL:
  https://stacks.cdc.gov/view/cdc/7228/cdc_7228_DS1.pdf
• File Type:
  [PDF - 1.17 MB ]