Update: Recommendations of the Advisory Committee on Immunization practices for use of hepatitis A vaccine for postexposure prophylaxis and for preexposure prophylaxis for international travel

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Nelson, Noele P. ; Link-Gelles, Ruth ; Hofmeister, Megan G. ; Romero, José R. ; Moore, Kelly L. ; Ward, John W. ; Schillie, Sarah F.
• Corporate Authors:
  United States. Advisory Committee on Immunization Practices. ; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of Viral Hepatitis.
• Description:
  Postexposure prophylaxis (PEP) with hepatitis A (HepA) vaccine or immune globulin (IG) effectively prevents infection with hepatitis A virus (HAV) when administered within 2 weeks of exposure. Preexposure prophylaxis against HAV infection through the administration of HepA vaccine or IG provides protection for unvaccinated persons traveling to or working in countries that have high or intermediate HAV endemicity. The Advisory Committee on Immunization Practices (ACIP) Hepatitis Vaccines Work Group conducted a systematic review of the evidence for administering vaccine for PEP to persons aged >40 years and reviewed the HepA vaccine efficacy and safety in infants and the benefits of protection against HAV before international travel. The February 21, 2018, ACIP recommendations update and supersede previous ACIP recommendations for HepA vaccine for PEP and for international travel. Current recommendations include that HepA vaccine should be administered to all persons aged ≥12 months for PEP. In addition to HepA vaccine, IG may be administered to persons aged >40 years depending on the provider's risk assessment. ACIP also recommended that HepA vaccine be administered to infants aged 6-11 months traveling outside the United States when protection against HAV is recommended. The travel-related dose for infants aged 6-11 months should not be counted toward the routine 2-dose series. The dosage of IG has been updated where applicable (0.1 mL/kg). HepA vaccine for PEP provides advantages over IG, including induction of active immunity, longer duration of protection, ease of administration, and greater acceptability and availability.
• Subjects:
  Adolescent Adult Advisory Committees Child Child, Preschool Full Report Hepatitis A Hepatitis A Vaccines Humans Immunization Immunization Schedule Immunoglobulins Infant Post-Exposure Prophylaxis Pre-Exposure Prophylaxis Travel Vaccines, Inactivated Young Adult

  More +
• Source:
  MMWR Morbidity Mortal Weekly Rep. 67(43):1216-1220
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6743a5
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  30383742
• Pubmed Central ID:
  PMC6319798
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Pages in Document:
  5 pdf pages
• Volume:
  67
• Issue:
  43
• Collection(s):
  Advisory Committee on Immunization Practices (ACIP) Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:10b700f5bd93ceb1853c14e84adac282375ef6335d18cff58462f066f4a3ad78b65c16ca66824bc534150fa8130fc3a48b661053ff15b534454c88d32913b149
• Download URL:
  https://stacks.cdc.gov/view/cdc/70160/cdc_70160_DS1.pdf
• File Type:
  [PDF - 109.44 KB ]