Details:

Personal Author:
Kretsinger, Katrina. ; Broder, Karen R. ; Cortese, Margaret M. ; Joyce, Patricia ; Ortega-Sanchez, Ismael ; ... More +
Kretsinger, Katrina. ; Broder, Karen R. ; Cortese, Margaret M. ; Joyce, Patricia ; Ortega-Sanchez, Ismael ; Lee, Grace M. ; Tiwari, Tejpratap ; Cohn, Amanda C. ; Slade, Barbara A. ; Iskander, John K. ; Mijalski, Christina M. ; Brown, Kristin H. ; Murphy, Trudy V. ; Less -
Corporate Authors:
National Immunization Program (Centers for Disease Control and Prevention ; Centers for Disease Control and Prevention (U.S.), Immunization Safety Office. ; United States, Advisory Committee on Immunization Practices ;
National Immunization Program (Centers for Disease Control and Prevention ; Centers for Disease Control and Prevention (U.S.), Immunization Safety Office. ; United States, Advisory Committee on Immunization Practices ; Less -
Description:
On June 10, 2005, a tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (Tdap) formulated for use in adults and adolescents was licensed in the United States for persons aged 11--64 years (ADACEL®, manufactured by sanofi pasteur, Toronto, Ontario, Canada). Prelicensure studies demonstrated safety and efficacy, inferred through immunogenicity, against tetanus, diphtheria, and pertussis when Tdap was administered as a single booster dose to adults. To reduce pertussis morbidity among adults and maintain the standard of care for tetanus and diphtheria prevention and to reduce the transmission of pertussis to infants and in health-care settings, the Advisory Committee on Immunization Practices (ACIP) recommends that: 1) adults aged 19--64 years should receive a single dose of Tdap to replace tetanus and diphtheria toxoids vaccine (Td) for booster immunization against tetanus, diphtheria, and pertussis if they received their last dose of Td >10 years earlier and they have not previously received Tdap; 2) intervals shorter than 10 years since the last Td may be used for booster protection against pertussis; 3) adults who have or who anticipate having close contact with an infant aged <12 months (e.g., parents, grandparents aged <65 years, child-care providers, and health-care personnel) should receive a single dose of Tdap to reduce the risk for transmitting pertussis. An interval as short as 2 years from the last Td is suggested; shorter intervals can be used. When possible, women should receive Tdap before becoming pregnant. Women who have not previously received Tdap should receive a dose of Tdap in the immediate postpartum period; 4) health-care personnel who work in hospitals or ambulatory care settings and have direct patient contact should receive a single dose of Tdap as soon as feasible if they have not previously received Tdap. An interval as short as 2 years from the last dose of Td is recommended; shorter intervals may be used. These recommendations for use of Tdap in health-care personnel are supported by the Healthcare Infection Control Practices Advisory Committee (HICPAC). This statement 1) reviews pertussis, tetanus and diphtheria vaccination policy in the United States; 2) describes the clinical features and epidemiology of pertussis among adults; 3) summarizes the immunogenicity, efficacy, and safety data of Tdap; and 4) presents recommendations for the use of Tdap among adults aged 19--64 years.
Content Notes:
prepared by Katrina Kretsinger ... [et al.] "The material in this report originated in the National Center for Immunization and Respiratory Diseases (proposed), Anne Schuchat, MD, Director; Division of Bacterial Diseases (proposed), Alison Mawle, PhD, (Acting) Director, and the Office of the Chief Science Officer, Tanja Popovic, MD, (Acting) Chief Science Officer; and Immunization Safety Office, Robert Davis, MD, Director. Includes bibliographical references (p. 27-33). JCSmith 1/13/2014
Subject:
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Administration & Dosage
Diphtheria
Diphtheria-Tetanus-acellular Pertussis Vaccines
Diphtheria-Tetanus-Pertussis Vaccine
Epidemiology
Immunization, Secondary
Immunization Schedule
Prevention & Control
Standards
Tetanus
Vaccination
Whooping Cough
Diphtheria-Tetanus-acellular Pertussis Vaccines/Administration & Dosage
Diphtheria-Tetanus-Pertussis Vaccine/Administration & Dosage
Diphtheria/Epidemiology
Diphtheria/Prevention & Control
Immunization, Secondary/Standards/United States
Tetanus/Epidemiology
Tetanus/Prevention & Control
Vaccination/Standards/United States
Whooping Cough/Epidemiology
Whooping Cough/Prevention & Control

Source:
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports / Centers for Disease Control. 2006 ; 55(RR-17):1-37.;
Series:
MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports ; v. v. 55, no. RR-17;
Document Type:
Journal Issue ;
Genre:
Practice Guideline ;
Place as Subject:
United States ;
Collection(s):
Guidelines and Recommendations
Stephen B. Thacker CDC Library collection
Advisory Committee on Immunization Practices (ACIP)
Main Document Checksum:
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urn:sha256:e87a3b51de2a17278cc17a13bcabcb9f5ce7fea8e67c59ec72b563b618263648
File Type:

Supporting Files

• No Additional Files

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