Screening for phenylketonuria in New York City. Threshold values reconsidered.

Hansen, H; Shahidi, A; Stein, Z A

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Screening for phenylketonuria in New York City. Threshold values reconsidered.

1978 May-Jun
By Hansen, H ; Shahidi, A ; Stein, Z A
Source: Public Health Rep. 93(3):246-251

[PDF-982.12 KB]

English

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Public Health Rep
Personal Author:

Hansen, H ; Shahidi, A ; Stein, Z A

Hansen, H ; Shahidi, A ; Stein, Z A Less -
Description:

In New York City from 1966 to 1970, almost all 736,469 newborns were screened for phenylketonuria (PKU). Among 1,094 infants with presumptive positive test results, 763 were followed up and 46 of them were judged to require preventive treatment. The considerable annual variation observed in the frequency of values of 4 to 6 mg/100 ml bood phenylalanine suggested low reliability at this level. Screening test results of 4 mg/100 ml, with no cases detected among them, represented 53% of all false positive results; newborns with 6 mg/100 ml results yielded 1 infant in need of treatment and accounted for 40% of the false positive results. The large volume of presumptive positive results generated by these levels presumably contributed to incomplete followup. If the threshold value for followup were raised, the effectiveness and the efficiency of the screening program could be improved. The experiences of other large PKU programs in the United States support these observations.
Subjects:

[+]

False Positive Reactions Follow-Up Studies Humans Infant, Newborn Phenylalanine Phenylketonurias Referral And Consultation Research Article
Source:

Public Health Rep. 93(3):246-251
Pubmed ID:

652946
Pubmed Central ID:

PMCnull
Document Type:

Journal Article
Place as Subject:

New York City, NY
Volume:

93
Issue:

3
Collection(s):

Public Health Reports
Main Document Checksum:

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urn:sha256:2c28e84b8c9dd93c34dbd9d794dc6e3a06d49a2899bd3ebd235772fa5730cef3
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https://stacks.cdc.gov/view/cdc/65434/cdc_65434_DS1.pdf
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Screening for phenylketonuria in New York City. Threshold values reconsidered.

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