Uptake and safety of Hepatitis B vaccination during pregnancy: A Vaccine Safety Datalink study☆

Details

• Journal Article:
  Vaccine
• Personal Author:
  Groom, Holly C. ; Irving, Stephanie A. ; Koppolu, Padma ; Smith, Ning ; Vazquez-Benitez, Gabriela ; Kharbanda, Elyse O. ; Daley, Matthew F. ; Donahue, James G. ; Getahun, Darios ; Jackson, Lisa A. ; Kawai, Alison Tse ; Klein, Nicola P. ; McCarthy, Natalie L. ; Nordin, James D. ; Sukumaran, Lakshmi ; Naleway, Allison L.
• Description:
  Introduction:
  
  Hepatitis B virus (HBV) infection acquired during pregnancy can pose a risk to the infant at birth that can lead to significant and lifelong morbidity. Hepatitis B vaccine (HepB) is recommended for anyone at increased risk for contracting HBV infection, including pregnant women. Limited data are available on the safety of HepB administration during pregnancy.
  
  Objectives:
  
  To assess the frequency of maternal HepB receipt among pregnant women and evaluate the potential association between maternal vaccination and pre-specified maternal and infant safety outcomes.
  
  Methods:
  
  We examined a retrospective cohort of pregnancies in the Vaccine Safety Datalink (VSD) resulting in live birth outcomes from 2004 through 2015. Eligible pregnancies in women aged 12-55 years who were continuously enrolled from 6 months pre-pregnancy to 6 weeks postpartum in VSD integrated health systems were included. We compared pregnancies with HepB exposure to those with other vaccine exposures, and to those with no vaccine exposures. High-risk conditions for contracting HBV infection were identified up to one-year prior to or during the pregnancy using ICD-9 codes. Maternal and fetal adverse events were also evaluated according to maternal HepB exposure status.
  
  Results:
  
  Among over 650,000 pregnancies in the study period, HepB was administered at a rate of 2.1 per 1000 pregnancies (n= 1399), commonly within the first 5 weeks of pregnancy. Less than 3% of the HepB-exposed group had a high-risk ICD-9 code indicating need for HepB; this was similar to the rate among HepB unvaccinated groups. There were no significant associations between HepB exposure during pregnancy and gestational hypertension, gestational diabetes, pre-eclampsia/eclampsia, cesarean delivery, pre-term delivery, low birthweight or small for gestational age infants.
  
  Conclusions:
  
  Most women who received maternal HepB did not have high-risk indications for vaccination. No increased risk for the adverse events that were examined were observed among women who received maternal HepB or their offspring.
  
  
• Subjects:
  Adolescent Adult Child Female Hepatitis B Hepatitis B Vaccines Humans Middle Aged Pregnancy Retrospective Studies Vaccination Young Adult

  More +
• Keywords:
  Chlorination Hepatitis B Vaccine Household Water Treatment Safe Water Storage Vaccine Safety
• Source:
  Vaccine. 36(41):6111-6116
• DOI:
  http://dx.doi.org/10.1016/j.vaccine.2018.08.074
• Pubmed ID:
  30194002
• Pubmed Central ID:
  PMC6325631
• Document Type:
  Text
• Funding:
  CC999999/Intramural CDC HHSUnited States/
• Genre:
  Journal Article
• Volume:
  36
• Issue:
  41
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6c0a6ab5461987f5c237222d392a0f89e2b8a1496a3823fa18daa3bf80ac8694c81f2b0d880f9f1dc4c74d083415f76e0d1b37c178a5095b4f73aa5e2e5bc3cf
• Download URL:
  https://stacks.cdc.gov/view/cdc/61883/cdc_61883_DS1.pdf
• File Type:
  [PDF - 471.29 KB ]