Low and Decreasing Prevalence and Rate of False Positive HIV Diagnosis — Chókwè District, Mozambique, 2014–2017

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Shodell, Daniel ; Nelson, Robert ; MacKellar, Duncan ; Thompson, Ricardo ; Casavant, Isabelle ; Mugabe, Didier ; Pals, Sherri ; Ujamaa, Dawud ; Bonzela, Juvencio ; Cardoso, Judite ; Machava, Salvador ; Lourenço, Carlos ; Yang, Chunfu ; Parekh, Bharat ; Pathmanathan, Ishani ; Auld, Andrew F. ; Tamele, Stelio ; Ouane, Manuel Antonio ; Macome, Vania ; Chicuecue, Noela ; Amane, Guita ; Kohatsu, Luciana ; Honwana, Nely ; Wei, Stanley ; Kerndt, Peter R. ; Monterroso, Edgar ; Vergara, Alfredo
• Description:
  In 2017, rapid human immunodeficiency Virus (HIV) tTesting services enabled the HIV Diagnosis and treatment of approximately 15.3 million persons with HIV infection in sub-Saharan Africa with life-saving antiretroviral therapy (ART) (1). Although suboptimal tTesting practices and misdiagnoses have been reported in sub-Saharan Africa and elsewhere, Trends in population burden and rate of false positive HIV Diagnosis (false Diagnosis) have not been reported (2,3). Understanding the population prevalence and Trends of false Diagnosis is fundamental for guiding rapid HIV tTesting policies and practices. To help address this need, CDC analyzed data from 57,655 residents aged 15-59 years in the Chókwè Health and Demographic Surveillance System (CHDSS) in Mozambique to evaluate Trends in the rate (the percentage of false diagnoses among retested persons reporting a prior HIV Diagnosis) and population prevalence of false Diagnosis. From 2014 to 2017, the observed rate of false Diagnosis in CHDSS decreased from 0.66% to 0.00% (p<0.001), and the estimated population prevalence of false Diagnosis decreased from 0.08% to 0.01% (p = 0.0016). Although the prevalence and rate of false Diagnosis are low and have decreased significantly in CHDSS, observed false diagnoses underscore the importance of routine HIV retTesting before ART initiation and implementation of comprehensive rapid HIV test quality management systems (2,4,5).
• Subjects:
  Adolescent Adult False Positive Reactions Female Full Report HIV Infections Humans Male Middle Aged Prevalence Young Adult

  More +
• Source:
  MMWR Morbidity Mortal Weekly Rep. 67(49):1363-1368
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6749a3
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  30543600
• Pubmed Central ID:
  PMC6300074
• Document Type:
  Journal Article
• Place as Subject:
  Mozambique
• Pages in Document:
  6 pdf pages
• Volume:
  67
• Issue:
  49
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:0f80826da170cf985559ebce18f748081bcba07d902539ac1b952beb1292f5be39db6e92b722bfa2704c4be166b215e24d08a4ff32474561a86cf460faad3926
• Download URL:
  https://stacks.cdc.gov/view/cdc/61555/cdc_61555_DS1.pdf
• File Type:
  [PDF - 127.38 KB ]