Outbreak of HIV Infection Linked to Nosocomial Transmission, China, 2016–2017

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pan, Xiaohong ; Jiang, Jianmin ; Ma, Qiaoqin ; Zhang, Jiafeng ; Yang, Jiezhe ; Chen, Wanjun ; Ding, Xiaobei ; Fan, Qin ; Guo, Zhihong ; Xia, Yan ; Xia, Shichang ; Wu, Zunyou
• Description:
  On January 25, 2017, a physician from ZC Hospital in Hangzhou, China, reported to the Zhejiang Provincial Center for Disease Control and Prevention that a potential HIV outbreak might have occurred during lymphocyte immunotherapy (LIT) performed at the hospital on December 30, 2016. We immediately began investigating and identified the index case-patient as an LIT patient's husband who donated lymphocytes for his wife's LIT and later screened HIV-reactive. Subsequent contamination by a technician resulted in the potential exposure of 34 LIT patients. Acute HIV infection was diagnosed in 5 persons. Phylogenetic analysis confirmed that the HIV-1 gag, pol, and env gene sequences from the index and outbreak-related cases had >99.5% similarity. Rapid investigation and implementation of effective control measures successfully controlled the outbreak. This incident provides evidence of a lapse in infection control causing HIV transmission, highlighting the need for stronger measures to protect patients from infectious disease exposure.
• Subjects:
  Adult Antiretroviral Therapy, Highly Active Coinfection Cross Infection/diagnosis Cross Infection/epidemiology Cross Infection/history Cross Infection/transmission Disease Outbreaks Female History, 21st Century HIV-1 HIV Infections/diagnosis HIV Infections/epidemiology HIV Infections/history HIV Infections/transmission Humans Male Phylogeny Population Surveillance Pre-Exposure Prophylaxis RNA, Viral Sentinel Surveillance Synopsis Treatment Outcome

  More +
• Source:
  Emerg Infect Dis. 24(12):2141-2149
• Pubmed ID:
  30457542
• Pubmed Central ID:
  PMC6256388
• Document Type:
  Journal Article
• Place as Subject:
  China
• Location:
  Asia
• Volume:
  24
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:de04fe739e0c46d2ebc8c47b9365ecb96ce18c40a6ab12347084365eb2fac0c6
• Download URL:
  https://stacks.cdc.gov/view/cdc/61334/cdc_61334_DS1.pdf
• File Type:
  [PDF - 2.07 MB ]