Poor clinical outcomes associated with community-onset urinary tract infections due to extended-spectrum cephalosporin-resistant Enterobacteriaceae

Details

• Alternative Title:
  Infect Control Hosp Epidemiol
• Personal Author:
  Anesi, Judith ; Lautenbach, Ebbing ; Nachamkin, Irving ; Garrigan, Charles ; Bilker, Warren B. ; Omorogbe, Jacqueline ; Dankwa, Lois ; Wheeler, Mary ; Tolomeo, Pam ; Han, Jennifer H.
• Corporate Authors:
  CDC Prevention Epicenters Program
• Description:
  Objective:
  
  Resistance to extended-spectrum cephalosporins (ESC) among Enterobacteriaceae (EB) is increasingly prevalent. We sought to determine the clinical outcomes associated with community-onset ESC-resistant (ESC-R) EB urinary tract infections (UTIs) in a United States (US) health system.
  
  Design:
  
  Retrospective cohort study
  
  Patients:
  
  All patients presenting to the Emergency Departments (EDs) or outpatient practices with EB UTIs between 2010 and 2013 were included. Exposed patients had ESC-R EB UTIs. Unexposed patients had ESC-susceptible EB UTIs and were matched to exposed subjects 1:1 on study year. Multivariable logistic regression analyses were performed to evaluate the association between ESC-R EB UTI and the outcomes of clinical failure and inappropriate initial antibiotic therapy (IIAT).
  
  Results:
  
  A total of 302 patients with community-onset EB UTI were included, with 151 exposed and unexposed. On multivariable analyses, UTI due to an ESC-R EB was significantly associated with clinical failure (odds ratio [OR] 7.07, 95% confidence interval [CI] 3.16–15.82, P value <0.01). Other independent risk factors for clinical failure included infection with Citrobacter species and need for hemodialysis. UTI due to an ESC-R EB was also significantly associated with IIAT (OR 4.40, 95% CI 2.64–7.33, P value <0.01).
  
  Conclusions:
  
  Community-onset UTI due to an ESC-R EB organism is significantly associated with clinical failure, which may be due in part to IIAT. Further studies are needed to determine which patients in the community are at high risk for drug-resistant infection to help inform prompt diagnosis and appropriate antibiotic prescribing for ESC-R EB.
  
  
• Subjects:
  Article
• Source:
  Infect Control Hosp Epidemiol. 39(12):1431-1435.
• Pubmed ID:
  30375298
• Pubmed Central ID:
  PMC6289636
• Document Type:
  Journal Article
• Funding:
  K24 AI080942/AI/NIAID NIH HHS/United States ; L30 AI133754/AI/NIAID NIH HHS/United States ; UM1 AI104681/AI/NIAID NIH HHS/United States ; R18 HS020002/HS/AHRQ HHS/United States ; U54 CK000163/CK/NCEZID CDC HHS/United States ; K01 AI103028/AI/NIAID NIH HHS/United States
• Volume:
  39
• Issue:
  12
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:aecb07ff851ddb3acaf4561260b37ca1745596c5193c5c159ff104145bb927d2
• Download URL:
  https://stacks.cdc.gov/view/cdc/61246/cdc_61246_DS1.pdf
• File Type:
  [PDF - 68.72 KB ]