Details:

Alternative Title:
Dermatol Surg
Publisher's site:
http://dx.doi.org/10.1097/DSS.0000000000000602
Personal Author:
Arron, Sarah T. ; Raymond, Amanda K. ; Yanik, Elizabeth L. ; Castenson, David ; McCulloch, Charles E. ; ... More +
Arron, Sarah T. ; Raymond, Amanda K. ; Yanik, Elizabeth L. ; Castenson, David ; McCulloch, Charles E. ; Clarke, Christina A. ; Paddock, Lisa E. ; Niu, Xiaoling ; Engels, Eric A. ; Less -
Description:
BACKGROUND There are limited data on outcomes in transplant recipients with a history of pretransplant melanoma. OBJECTIVE To determine whether pretransplant melanoma is associated with differences in survival or posttransplant melanoma risk. MATERIALS AND METHODS We evaluated the outcomes of 185,039 US transplant recipients from the Transplant Cancer Match Study. We also evaluated the impact of transplantation on 141,441 patients with melanoma identified in cancer registries. RESULTS There were 336 transplant recipients (0.18%) with pretransplant melanoma; they had increased risk of melanoma-specific mortality (hazard ratio [HR], 27; 95% confidence interval [CI], 11–64, p < .0001), overall mortality (HR, 1.3; 95% CI, 1.0–1.5, p = .02), and incident melanoma (HR, 5.4; 95% CI, 2.9–9.8, p < .0001) after transplant, compared with recipients without pretransplant melanoma. The 10-year absolute risk difference was 2.97% for melanoma-specific mortality, 3.68% for incident melanoma, and 14.32% for overall mortality. Among the 141,441 patients with melanoma in the general population, 68 (0.05%) subsequently received a transplant. Transplantation increased melanoma-specific mortality, but not significantly (HR, 1.7; 95% CI, 0.61–4.5, p = .32). CONCLUSION Pretransplant melanoma is associated with increased melanoma-specific mortality, overall mortality, and incident melanoma after transplant. Nonetheless, the rarity of melanoma-related events supports the current practice for listing transplant candidates with a history of melanoma.
Subject:
[+]
Adolescent
Adult
Aged
Aged, 80 And Over
Article
Cause Of Death
Humans
Melanoma
Middle Aged
Neoplasm Recurrence, Local
Neoplasms, Second Primary
Risk Factors
Skin Neoplasms
Transplant Recipients
Young Adult

Source:
Dermatol Surg. 42(2):157-166.
Pubmed ID:
26818209
Pubmed Central ID:
PMC6263147
Document Type:
Journal Article ;
Funding:
HHSN261201000034C/PHS HHS/United States ; 5U58DP000824-04/DP/NCCDPHP CDC HHS/United States ; N01-PC-35142/PC/NCI NIH HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; HHSN261201000036C/PHS HHS/United States ; ... More +
HHSN261201000034C/PHS HHS/United States ; 5U58DP000824-04/DP/NCCDPHP CDC HHS/United States ; N01-PC-35142/PC/NCI NIH HHS/United States ; 5658DP000805-04/DP/NCCDPHP CDC HHS/United States ; HHSN261201000036C/PHS HHS/United States ; HSN261201000032C/PHS HHS/United States ; N01-PC-35137/PC/NCI NIH HHS/United States ; N01-PC-35139/PC/NCI NIH HHS/United States ; U58DP000832/DP/NCCDPHP CDC HHS/United States ; U58DP003879/DP/NCCDPHP CDC HHS/United States ; 5U58DP000812-03/DP/NCCDPHP CDC HHS/United States ; U58 DP000848-04/DP/NCCDPHP CDC HHS/United States ; N01-PC-2013-00021/PC/NCI NIH HHS/United States ; HHSN261201000035C/PHS HHS/United States ; HHSN261201000026C/PHS HHS/United States ; HHSN261201300021I/PHS HHS/United States ; 5U58/DP003931-02/DP/NCCDPHP CDC HHS/United States ; ZIA CP010150-18/NULL/Intramural NIH HHS/United States ; Intramural NIH HHS/United States ; 1U58 DP000807-01/DP/NCCDPHP CDC HHS/United States ; HHSH250201000018C/PHS HHS/United States ; HHSN261201000024C/PHS HHS/United States ; HHSN261201000037C/PHS HHS/United States ; 5U58DP003875-01/DP/NCCDPHP CDC HHS/United States ; HHSH234200537009C/PHS HHS/United States ; N01-PC-35143/PC/NCI NIH HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:f5a995ba704cedab4868e13d1e75f4ca08441aabdd971e6d8c39905242749a1c
File Type:

Supporting Files

• 	nihms-997968-f0001.gif	gif
  	nihms-997968-f0001.jpg	jpeg
  	nihms-997968-f0002.gif	gif
  	nihms-997968-f0002.jpg	jpeg
  	nihms-997968.nxml	xml

More +