Seroprevalence of HPV 6, 11, 16 and 18 and correlates of exposure in unvaccinated women aged 16–64 years in Puerto Rico

Details

• Alternative Title:
  Papillomavirus Res
• Personal Author:
  Ortiz, A.P. ; Tortolero-Luna, G. ; Romaguera, J. ; Pérez, C.M. ; González, D. ; Muñoz, C. ; González, L. ; Marrero, E. ; Suárez, E. ; Palefsky, J.M. ; Panicker, G. ; Unger, E.R.
• Description:
  Background
  
  To understand risk factors for HPV exposure in Puerto Rican women, we evaluated HPV 6, 11, 16, and 18 serology in women aged living in the San Juan metropolitan area.
  
  Methods
  
  As part of a cross-sectional study, a population-based sample of 524 HPV unvaccinated Hispanic women ages 16–64 years completed face-to-face and computer assisted interviews and provided blood and self-collected anal and cervical specimens. Serology used multiplex virus-like particle based-IgG ELISA and HPV DNA was detected with L1-consensus PCR.
  
  Results
  
  32% and 47% were seropositive to HPV types included in the bivalent (16/18) and quadrivalent (6/11/16/18) vaccines, respectively. Type-specific seroprevalence was HPV6 − 29%, HPV11 − 18%, HPV16 − 23%, and HPV18 − 17%; seroprevalence was high in the youngest age-group (16–19: 26–37%). HPV seropositivity was associated with having ≥ 3 lifetime sexual partners (OR=2.5, 95% CI=1.7–3.9) and detection of anogenital HPV DNA (OR=1.8, 95% CI=1.2–2.6).
  
  Conclusions
  
  The high cumulative exposure of HPV vaccine types 6/11/16/18 in this Hispanic population was influenced by factors related to HPV exposure through sexual behavior. High seroprevalence in the youngest age-group indicates early age of exposure to HPV in Puerto Rico, highlighting the need for HPV vaccination starting prior to age 16.
  
  
• Subjects:
  Article
• Source:
  Papillomavirus Res. 2018; 5:109-113.
• Pubmed ID:
  29555601
• Pubmed Central ID:
  PMC5886958
• Document Type:
  Journal Article
• Funding:
  U54 MD007587/MD/NIMHD NIH HHS/United States ; SC2 AI090922/AI/NIAID NIH HHS/United States ; U54 RR026139/RR/NCRR NIH HHS/United States
• Place as Subject:
  Puerto Rico
• Volume:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a0ef4f03d96819d4b77954b3a647c79361b097e2d710bfefd4c8853bbb47b191
• Download URL:
  https://stacks.cdc.gov/view/cdc/60846/cdc_60846_DS1.pdf
• File Type:
  [PDF - 246.98 KB ]