Details:

Alternative Title:
J Infect Dis
Publisher's site:
http://dx.doi.org/10.1093/infdis/jiy522
Personal Author:
Barkume, Caitlin ; Date, Kashmira ; Saha, Samir K ; Qamar, Farah Naz ; Sur, Dipika ; ... More +
Barkume, Caitlin ; Date, Kashmira ; Saha, Samir K ; Qamar, Farah Naz ; Sur, Dipika ; Andrews, Jason R ; Luby, Stephen P ; Khan, M Imran ; Freeman, Alex ; Yousafzai, Mohammad Tahir ; Garrett, Denise ; Less -
Description:
Objective The objective of Phase I of the Surveillance for Enteric Fever in Asia Project (SEAP), a multiphase surveillance study characterizing the burden of disease in South Asia, was to inform data collection for prospective surveillance and to capture clinical aspects of disease. Methods Through a retrospective record review conducted at hospitals in Bangladesh, India, Nepal, and Pakistan, we examined laboratory and clinical records to assess the culture positivity rate for Salmonella Typhi and Salmonella Paratyphi, age and sex distribution, and antimicrobial susceptability in each country. Results Of all blood cultures performed in Bangladesh, India, Nepal, and Pakistan, 1.5%, 0.43%, 2%, and 1.49%, respectively, were positive for S. Typhi and 0.24%, 0.1%, 0.5%, and 0.67%, respectively, were positive for S. Paratyphi. A higher proportion of laboratory-confirmed infections in Bangladesh and Pakistan were aged ≤5 years, while India and Nepal had a higher proportion of participants aged 15–25 years. In all countries, the sex of the majority of participants was male. The majority of isolates in all countries were resistant to fluoroquinolones, with a high proportion also resistant to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole. Discussion Enteric fever remains endemic in South Asia. Data generated by this study can help inform strategies for implementation and evaluation of prevention and control measures.
Subject:
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Antimicrobial Resistance
Enteric Fever
Paratyphoid
Salmonella
Supplement Articles
Typhoid

Source:
J Infect Dis. 2018; 218(Suppl 4):S188-S194.
Pubmed ID:
30304505
Pubmed Central ID:
PMC6226726
Document Type:
Journal Article ;
Place as Subject:
Asia ;
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:56d3b6e44633bbb2c484382b4f3a194eef76c2d6aa99a7e892a2abcd7d92de0b
File Type:

Supporting Files

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