Recommendations of the Advisory Committee on Immunization Practices for Use of a Hepatitis B Vaccine with a Novel Adjuvant.

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Schillie, Sarah F. ; Harris, Aaron ; Link-Gelles, Ruth ; Romero, José ; Ward, John ; Nelson, Noele
• Corporate Authors:
  United States. Advisory Committee on Immunization Practices. ; National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention (U.S.). Division of Viral Hepatitis.
• Description:
  Hepatitis B (HepB) vaccination is the primary means of preventing infections and complications caused by hepatitis B virus (HBV). On February 21, 2018, the Advisory Committee on Immunization Practices (ACIP) recommended Heplisav-B (HepB-CpG), a yeast-derived vaccine prepared with a novel adjuvant, administered as a 2-dose series (0, 1 month) for use in persons aged ≥18 years. The ACIP Hepatitis Vaccines Work Group conducted a systematic review of the evidence, including data from four randomized controlled trials assessing prevention of HBV infection and six randomized controlled trials assessing adverse events in adults. Seroprotective antibody to hepatitis B surface antigen (anti-HBs) levels were achieved in 90.0%–100.0% of subjects receiving HepB-CpG (Dynavax Technologies Corporation), compared with 70.5%–90.2% of subjects receiving Engerix-B (GlaxoSmithKline Biologicals). The benefits of protection with 2 doses administered over 1 month make HepB-CpG an important option for prevention ofHBV.
• Subjects:
  Adjuvants, Immunologic Adolescent Adult Advisory Committees Full Report Hepatitis B Hepatitis B Vaccines Humans Immunization Schedule Practice Guidelines As Topic Randomized Controlled Trials As Topic

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• Source:
  MMWR Morbidity Mortal Weekly Rep. 67(15):455-458.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6715a5
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  29672472
• Pubmed Central ID:
  PMC6191098
• Document Type:
  Journal Article
• Place as Subject:
  United States
• Location:
  North America
• Pages in Document:
  4 pdf pages
• Volume:
  67
• Issue:
  15
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR) Advisory Committee on Immunization Practices (ACIP)
• Main Document Checksum:
  urn:sha-512:efb61e3297dddf0dea995b74c1a1060bfeb2b714f3a949fd26580f9063b2179d52da856b5a5950601c3aae690756cadbd10659cf05e6382dcfd51adbcb630855
• Download URL:
  https://stacks.cdc.gov/view/cdc/59967/cdc_59967_DS1.pdf
• File Type:
  [PDF - 173.62 KB ]