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NIOSH skin notation (SK) profile; acrylonitrile [CAS No. 107-13-1]
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NIOSH skin notation (SK) profile; acrylonitrile [CAS No. 107-13-1]
  • Description:
    Foreword -- Abbreviations -- Glossary -- Acknowledgments -- 1. Introduction -- 1.1. General Substance Information -- 1.2. Purpose -- 1.3. Overview of SK Assignment for Acrylonitrile -- 2. Systemic Toxicity from Skin Exposure (SK: SYS) -- 3. Direct Effects on Skin (SK: DIR) -- 4 Immune-mediated Responses (SK: SEN) -- 5. Summary -- References -- Appendix: Calculation of the SI Ratio for Acrylonitrile

    "This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with acrylonitrile and (2) the rationale behind the hazard-specific skin notation (SK) assignment for acrylonitrile. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to acrylonitrile. A literature search was conducted through July 2010 to identify information on acrylonitrile, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to acrylonitrile. Acrylonitrile is potentially capable of causing numerous adverse health effects following skin contact. A critical review of available data has resulted in the following SK assignment for acrylonitrile: SK: SYS (FATAL)-DIR (IRR)-SEN. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for acrylonitrile." - NIOSHTIC-2

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