Welcome to CDC stacks |
Stacks Logo
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.
Clear All Simple Search
Advanced Search
NIOSH skin notation (SK) profile; dinitrobenzene (DNB) [CAS No. 25154-54-5]; m-dinitrobenzene (m-DNB) [CAS No. 99-65-0]; o-dinitrobenzene (o-DNB) [CAS No. 528-29-0]; p-dinitrobenzene (p-DNB) [CAS No. 100-25-4]
Filetype[PDF-816.46 KB]

  • Alternative Title:
    Dinitrobenzene (DNB) [CAS No. 25154-54-5] ; M-dinitrobenzene (m-DNB) [CAS No. 99-65-0] ; O-dinitrobenzene (o-DNB) [CAS No. 528-29-0] ; NIOSH skin notation (SK) profile : dinitrobenzene (DNB), m-dinitrobenzene (m-DNB), o-dinitrobenzene (o-DNB), p-dinitrobenzene (p-DNB) ; P-dinitrobenzene (p-DNB) [CAS No. 100-25-4] ;
  • Description:
    Foreword -- Abbreviations -- Glossary -- Acknowledgments -- 1. Introduction -- 1.1. General Substance Information -- 1.2. Purpose -- 1.3. Overview of SK Assignment for DNB -- 2. Systemic Toxicity from Skin Exposure (SK: SYS) -- 3. Direct Effects on Skin (SK: DIR) -- 4 Immune-mediated Responses (SK: SEN) -- 5. Summary -- References -- Appendix: Calculation of the SI Ratio for DNB

    "This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with DNB and (2) the rationale behind the hazard-specific skin notation (SK) assignment for DNB. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to DNB. A literature search was conducted through July 2010 to identify information on DNB, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to DNB. DNB is potentially capable of causing adverse systemic effects following skin contact. A critical review of available data has resulted in the following SK assignment for DNB: SK: SYS. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for DNB." - NIOSHTIC-2

  • Content Notes:
    "This document was developed by the Education and Information Division, Paul Schulte, Ph.D., Director. G. Scott Dotson, Ph.D. was the project officer for this document. Other NIOSH personnel, in particular Geraci, Ph.D., Thomas J. Lentz, Ph.D., Michael Luster, Ph.D., Richard Niemeier, Ph.D., and Aaron Sussell, Ph.D., contributed to its development by providing technical reviews and comments. The basis for this document was a report contracted by NIOSH and prepared by Bernard Gadagbui, Ph.D., and Andrew Maier, Ph.D. (Toxicology Excellence for Risk Assessment [TERA])." -- p. ix ; Includes bibliographical references (p. 5-7). ;
  • Main Document Checksum:
  • Supporting Files:
    No Additional Files
No Related Documents.
You May Also Like: