Details:

Alternative Title:
PLoS One
Publisher's site:
http://dx.doi.org/10.1371/journal.pone.0203205
Personal Author:
Bozio, Catherine H. ; Abdul-Karim, Abass ; Abenyeri, John ; Abubakari, Braimah ; Ofosu, Winfred ; ... More +
Bozio, Catherine H. ; Abdul-Karim, Abass ; Abenyeri, John ; Abubakari, Braimah ; Ofosu, Winfred ; Zoya, Justina ; Ouattara, Mahamoudou ; Srinivasan, Velusamy ; Vuong, Jeni T. ; Opare, David ; Asiedu-Bekoe, Franklin ; Lessa, Fernanda C. Less -
Description:
Background

Increases in pneumococcal meningitis were reported from Ghanaian regions that lie in the meningitis belt in 2016–2017, despite introduction of 13-valent pneumococcal conjugate vaccine (PCV13) in 2012 using a 3-dose schedule (6, 10, and 14 weeks). We describe pneumococcal meningitis epidemiology in the Ghanaian Northern and Upper West regions across two meningitis seasons.

Methods

Suspected meningitis cases were identified using World Health Organization standard definitions. Pneumococcal meningitis was confirmed if pneumococcus was the sole pathogen detected by polymerase chain reaction, culture, or latex agglutination in cerebrospinal fluid collected from a person with suspected meningitis during December 2015-March 2017. Pneumococcal serotyping was done using PCR. Annual age-specific pneumococcal meningitis incidence (cases per 100,000 population) was calculated, adjusting for suspected meningitis cases lacking confirmatory testing.

Findings

Among 153 pneumococcal meningitis cases, 137 (89.5%) were serotyped; 100 (73.0%) were PCV13-type, including 85 (62.0%) that were serotype 1, a PCV13-targeted serotype. Persons aged ≥5 years accounted for 96.7% (148/153) of cases. Comparing 2015–2016 and 2016–2017 seasons, the proportion of non-serotype 1 PCV13-type cases decreased from 20.0% (9/45) to 4.1% (3/74) (p = 0.008), whereas the proportion that was serotype 1 was stable (71.1% (32/45) vs. 58.1% (43/74); p = 0.16). Estimated adjusted pneumococcal meningitis incidence was 1.8 in children aged <5 years and ranged from 6.8–10.5 in older children and adults.

Conclusions

High pneumococcal meningitis incidence with a large proportion of serotype 1 disease in older children and adults suggests infant PCV13 vaccination has not induced herd protection with this schedule in this high-transmission setting.


Subjects:
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Adolescent Adult Aged Biology And Life Sciences Child Child, Preschool Female Ghana Humans Immunization Schedule Infant Male Medicine And Health Sciences Meningitis, Pneumococcal Middle Aged People And Places Pneumococcal Vaccines Research And Analysis Methods Research Article Serogroup Streptococcus Pneumoniae Time Factors Vaccines, Conjugate Young Adult
Source:
PLoS One. 13(9)
Pubmed ID:
30192772
Pubmed Central ID:
PMC6128537
Document Type:
Journal Article
Collection(s):
Stephen B. Thacker CDC Library collection
Main Document Checksum:
[+]
urn:sha256:263e28a8e854527ccbeecd16a1228a6af373d5a2266a04a4b5c42f351af2b616
Download URL:
https://stacks.cdc.gov/view/cdc/59801/cdc_59801_DS1.pdf
File Type:

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