NIOSH skin notation (SK) profile; 2-ethoxyethanol (EE) [CAS No. 110-80-5]
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NIOSH skin notation (SK) profile; 2-ethoxyethanol (EE) [CAS No. 110-80-5]

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  • Alternative Title:
    2-ethoxyethanol (EE) [CAS No. 110-80-5];NIOSH skin notation profiles;EE;
  • Corporate Authors:
    National Institute for Occupational Safety and Health, Education and Information Division.
  • Description:
    "This Skin Notation Profile presents (1) a brief summary of technical data associated with skin contact with EE and (2) the rationale behind the hazard-specific skin notation (SK) assignment for EE. The SK assignment is based on the scientific rationale and logic outlined in the Current Intelligence Bulletin (CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 2009]. The summarized information and health hazard assessment are limited to an evaluation of the potential health effects of dermal exposure to EE. A literature search was conducted through July 2010 to identify information on EE, including but not limited to data relating to its toxicokinetics, acute toxicity, repeated-dose systemic toxicity, carcinogenicity, biological system/function-specific effects (including reproductive and developmental effects and immunotoxicity), irritation, and sensitization. Information was considered from studies of humans, animals, or appropriate modeling systems that are relevant to assessing the effects of dermal exposure to EE. EE is potentially capable of causing multiple toxic effects following skin contact. A critical review of available data has resulted in the following SK assignment for EE: SK: SYS. Table 1 provides an overview of the critical effects and data used to develop the SK assignment for EE." -- NIOSHTIC-2
  • Content Notes:
    "This document was developed by the Education and Information Division, Paul Schulte, Ph.D., Director. G. Scott Dotson, Ph.D. was the project officer for this docu-ment. Other NIOSH personnel, in particular Eric Esswein, M.Sc., Charles L. Geraci, Ph.D., Thomas J. Lentz, Ph.D., Richard Niemeier, Ph.D., and. Loren Tapp, M.D., con-tributed to its development by providing technical reviews and comments. The basis for this document was a report contracted by NIOSH and prepared by Bernard Gadagbui, Ph.D., and Andrew Maier, Ph.D. (Toxicology Excellence for Risk Assessment [TERA])." - p. ix

    Includes bibliographical references (p. 5-7).

  • Subjects:
  • Series:
    DHHS publication ; no. (NIOSH) 2011-153
  • Document Type:
    Pamphlet (or booklet)
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