Prevalence of Granulomas in Patients with Primary Immunodeficiency Disorders, United States: Data from National Healthcare Claims and the US Immunodeficiency Network Registry
Advanced Search
Select up to three search categories and corresponding keywords using the fields to the right. Refer to the Help section for more detailed instructions.

Search our Collections & Repository

For very narrow results

When looking for a specific result

Best used for discovery & interchangable words

Recommended to be used in conjunction with other fields

Dates

to

Document Data
Library
People
Clear All
Clear All

For additional assistance using the Custom Query please check out our Help Page

i

Prevalence of Granulomas in Patients with Primary Immunodeficiency Disorders, United States: Data from National Healthcare Claims and the US Immunodeficiency Network Registry

Filetype[PDF-174.61 KB]


English

Details:

  • Alternative Title:
    J Clin Immunol
  • Personal Author:
  • Description:
    Purpose:

    Granulomas are a potentially severe condition that can last for several years in persons with primary immunodeficiency disorders (PIDD). We assessed the prevalence of granulomas in patients with PIDD.

    Methods:

    We used the Truven Health MarketScan® 2005–2015 Commercial Claims and Encounters and 2006–2015 Medicaid databases, and The U.S. Immunodeficiency Network (USIDNET) PIDD registry (a program of the Immune Deficiency Foundation). Our study population consisted of persons age <65 years with PIDD, defined as persons with ≥2 claims with a diagnostic code for PIDD in MarketScan databases, or patients enrolled in USIDNET. Granulomas were identified using diagnostic codes in MarketScan or provider report in USIDNET. We calculated annual prevalence of PIDD and of granulomas among PIDD patients.

    Results:

    We identified 247,474 and 40,395 persons with PIDD among commercially- and Medicaid-insured persons, respectively. PIDD prevalence was 6.0/10,000 in 2005 and 11.7/10,000 in 2015 among commercially-insured persons; 5.5/10,000 in 2006 and 9.6/10,000 in 2015 among Medicaid-insured persons. The prevalence of granulomas among PIDD patients was 1.2% and 1.5% among commercially- and Medicaid-insured persons, respectively. In USIDNET, prevalence of granulomas was 4.4% (177/4,021). The proportion with granulomas was similar across age groups in MarketScan, but varied from 2% to 9% in USIDNET. The reported prevalence of granulomas differed depending on PIDD condition: 1–2% in the MarketScan data, and 0–13% in USIDNET.

    Conclusion:

    Granuloma prevalence in PIDD patients was 1–4%. Our study provides an estimate of the proportion of PIDD patients and suggests that granulomas are an uncommon occurrence among patients with PIDD.

  • Subjects:
  • Source:
  • Pubmed ID:
    30043271
  • Pubmed Central ID:
    PMC6155465
  • Document Type:
  • Funding:
  • Collection(s):
  • Main Document Checksum:
  • Download URL:
  • File Type:

You May Also Like

Checkout today's featured content at stacks.cdc.gov