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Prevalence of Granulomas in Patients with Primary Immunodeficiency Disorders, United States: Data from National Healthcare Claims and the US Immunodeficiency Network Registry
  • Published Date:
    July 24 2018
  • Source:
    J Clin Immunol. 38(6):717-726
  • Language:
Filetype[PDF-174.61 KB]

  • Alternative Title:
    J Clin Immunol
  • Description:
    Purpose: Granulomas are a potentially severe condition that can last for several years in persons with primary immunodeficiency disorders (PIDD). We assessed the prevalence of granulomas in patients with PIDD. Methods: We used the Truven Health MarketScan® 2005–2015 Commercial Claims and Encounters and 2006–2015 Medicaid databases, and The U.S. Immunodeficiency Network (USIDNET) PIDD registry (a program of the Immune Deficiency Foundation). Our study population consisted of persons age <65 years with PIDD, defined as persons with ≥2 claims with a diagnostic code for PIDD in MarketScan databases, or patients enrolled in USIDNET. Granulomas were identified using diagnostic codes in MarketScan or provider report in USIDNET. We calculated annual prevalence of PIDD and of granulomas among PIDD patients. Results: We identified 247,474 and 40,395 persons with PIDD among commercially- and Medicaid-insured persons, respectively. PIDD prevalence was 6.0/10,000 in 2005 and 11.7/10,000 in 2015 among commercially-insured persons; 5.5/10,000 in 2006 and 9.6/10,000 in 2015 among Medicaid-insured persons. The prevalence of granulomas among PIDD patients was 1.2% and 1.5% among commercially- and Medicaid-insured persons, respectively. In USIDNET, prevalence of granulomas was 4.4% (177/4,021). The proportion with granulomas was similar across age groups in MarketScan, but varied from 2% to 9% in USIDNET. The reported prevalence of granulomas differed depending on PIDD condition: 1–2% in the MarketScan data, and 0–13% in USIDNET. Conclusion: Granuloma prevalence in PIDD patients was 1–4%. Our study provides an estimate of the proportion of PIDD patients and suggests that granulomas are an uncommon occurrence among patients with PIDD.
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