Schistosoma mansoni Mass Drug Administration Regimens and Their Effect on Morbidity among Schoolchildren over a 5-Year Period—Kenya, 2010–2015

Details

• Alternative Title:
  Am J Trop Med Hyg
• Personal Author:
  Sircar, Anita D. ; Mwinzi, Pauline N. M. ; Onkanga, Isaac O. ; Wiegand, Ryan E. ; Montgomery, Susan P. ; Secor, W. Evan
• Description:
  Schistosomiasis control programs are designed to reduce morbidity by providing mass drug administration (MDA) of praziquantel to at-risk populations. We compared morbidity markers between two cohorts of Kenyan schoolchildren that initially had high prevalence of | infections. One cohort (| = 416 at year 1) received four rounds of annual MDA in a community-wide treatment (CWT) strategy. The other cohort (| = 386 at year 1) received school-based treatment (SBT) every other year over the 4-year period. We measured infection with | and soil-transmitted helminths (STH) as well as subtle morbidity markers at year 1, year 3, and year 5 and compared cohorts with mixed models after controlling for age and gender. At year 5, neither overall | prevalence nor the prevalence of high infection-intensity | infection was significantly reduced compared with baseline in either the CWT cohort (| = 277 remaining) or the SBT cohort (| = 235 remaining). Nevertheless, by year 5, children in both cohorts demonstrated significant decreases in wasting, ultrasound-detected organomegaly, and STH infection along with significantly improved pediatric quality-of-life scores compared with year 1. Stunting did not change over time, but children who were | egg-positive at year 5 had significantly more stunting than children without schistosomiasis. The only significant difference between arms at year 5 was a lower prevalence of STH infections in the CWT group.
• Subjects:
  Articles
• Source:
  Am J Trop Med Hyg. 2018; 99(2):362-369.
• Pubmed ID:
  29893197
• Pubmed Central ID:
  PMC6090338
• Document Type:
  Journal Article
• Place as Subject:
  Kenya
• Volume:
  99
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c2840830ab845ededf0aa71b808c8b259385eed5211ba26a587cc0669dc63170
• Download URL:
  https://stacks.cdc.gov/view/cdc/59279/cdc_59279_DS1.pdf
• File Type:
  [PDF - 644.80 KB ]