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Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines
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Sep 20 2017
Source: Comput Math Methods Med. 2017; 2017. -
Alternative Title:Comput Math Methods Med
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Description:Truncated power basis expansions and penalized spline methods are demonstrated for estimating nonlinear exposure-response relationships in the Cox proportional hazards model. R code is provided for fitting models to get point and interval estimates. The method is illustrated using a simulated data set under a known exposure-response relationship and in a data application examining risk of carpal tunnel syndrome in an occupational cohort.
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Pubmed ID:29312462
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Pubmed Central ID:PMC5632483
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