Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Malloy, Elizabeth J.; Kapellusch, Jay M.; Garg, Arun

doi:10.1155/2017/7518035

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Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Sep 20 2017

By Malloy, Elizabeth J. ; Kapellusch, Jay M. ; Garg, Arun ;

http://dx.doi.org/10.1155/2017/7518035

Source: Comput Math Methods Med. 2017; 2017.

[PDF-2.77 MB]

English

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Alternative Title:

Comput Math Methods Med

Publisher's site:

http://dx.doi.org/10.1155/2017/7518035

Personal Author:

Malloy, Elizabeth J. ; Kapellusch, Jay M. ; Garg, Arun ;

Description:

Truncated power basis expansions and penalized spline methods are demonstrated for estimating nonlinear exposure-response relationships in the Cox proportional hazards model. R code is provided for fitting models to get point and interval estimates. The method is illustrated using a simulated data set under a known exposure-response relationship and in a data application examining risk of carpal tunnel syndrome in an occupational cohort.

Subject:

[+]

Source:

Comput Math Methods Med. 2017 ; 2017.;

Pubmed ID:

29312462

Pubmed Central ID:

PMC5632483

Document Type:

Journal Article ;

Funding:

R01 OH010474/OH/NIOSH CDC HHS/United States ; U01 OH007917/OH/NIOSH CDC HHS/United States ;

Collection(s):

CDC Public Access

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Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

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