Estimating and Interpreting Effects from Nonlinear Exposure-Response Curves in Occupational Cohorts Using Truncated Power Basis Expansions and Penalized Splines

Details

• Alternative Title:
  Comput Math Methods Med
• Personal Author:
  Malloy, Elizabeth J. ; Kapellusch, Jay M. ; Garg, Arun
• Description:
  Truncated power basis expansions and penalized spline methods are demonstrated for estimating nonlinear exposure-response relationships in the Cox proportional hazards model. R code is provided for fitting models to get point and interval estimates. The method is illustrated using a simulated data set under a known exposure-response relationship and in a data application examining risk of carpal tunnel syndrome in an occupational cohort.
• Subjects:
  Adult Carpal Tunnel Syndrome Cohort Studies Computer Simulation Data Interpretation, Statistical Humans Occupational Diseases Proportional Hazards Models Risk Assessment Software Stress, Mechanical Upper Extremity

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• Source:
  Comput Math Methods Med. 2017; 2017.
• Pubmed ID:
  29312462
• Pubmed Central ID:
  PMC5632483
• Document Type:
  Journal Article
• Funding:
  R01 OH010474/OH/NIOSH CDC HHS/United States ; U01 OH007917/OH/NIOSH CDC HHS/United States
• Volume:
  2017
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8476fb725cbc3dec64779f02b2e2edbea420fa78edeee1d5bf3c8a4cfc3e0d13
• Download URL:
  https://stacks.cdc.gov/view/cdc/59019/cdc_59019_DS1.pdf
• File Type:
  [PDF - 2.77 MB ]