Clinic-based evaluation study of the diagnostic accuracy of a dual rapid test for the screening of HIV and syphilis in pregnant women in Nigeria

Details

• Alternative Title:
  PLoS One
• Personal Author:
  Olugbenga, Ijaodola ; Taiwo, Oyelade ; Laverty, Maura ; Ngige, Evelyn ; Anyaike, Chukwuma ; Bakare, Rasheed ; Ogunleye, Veronica ; Peterson Maddox, Brandy L. ; Newman, Daniel R. ; Gliddon, Harriet D. ; Ofondu, Eugenia ; Nurse-Findlay, Stephen ; Taylor, Melanie M.
• Description:
  Background
  
  Screening pregnant women for HIV and syphilis is recommended by WHO in order to reduce mother-to-child transmission. We evaluated the field performance, feasibility, and acceptability of a dual rapid diagnostic test (RDT) for HIV and syphilis test in antenatal clinic settings in Nigeria.
  
  Methods and findings
  
  Participants were recruited at 12 antenatal clinic sites in three states of Nigeria. All consenting individuals were tested according to the national HIV testing algorithm, as well as a dual RDT, the SD BIOLINE HIV/Syphilis Duo Test (Alere, USA), in the clinic. To determine sensitivity, specificity and concordance, whole blood samples were obtained for repeat RDT performance in the laboratory, as well as reference tests for HIV and syphilis. Dual test acceptability and operational characteristics were assessed among participants and clinic staff.
  
  Conclusions
  
  The SD BIOLINE HIV/Syphilis Duo Test showed a high overall diagnostic accuracy for HIV and a high specificity for syphilis diagnosis in antenatal clinic settings. This study adds to a growing body of evidence that supports the clinic-based use of dual tests for HIV and syphilis among pregnant women.
  
  
• Subjects:
  Adolescent Adult AIDS Serodiagnosis Ambulatory Care Facilities Antibodies, Bacterial Antibodies, Viral Female HIV HIV Infections Humans Immunoassay Infectious Disease Transmission, Vertical Mass Screening Pregnancy Pregnancy Complications, Infectious Reagent Kits, Diagnostic Sensitivity And Specificity Syphilis Syphilis Serodiagnosis Treponema Pallidum

  More +
• Source:
  PLoS One. 2018; 13(7).
• Pubmed ID:
  29990336
• Pubmed Central ID:
  PMC6038984
• Document Type:
  Journal Article
• Place as Subject:
  Nigeria
• Volume:
  13
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:91ddb63ab8d35316ae29e52198b3e8842832ed771123d729b8ff3d56b94dfd28
• Download URL:
  https://stacks.cdc.gov/view/cdc/58926/cdc_58926_DS1.pdf
• File Type:
  [PDF - 2.25 MB ]