Details:

Alternative Title:
Epilepsia
Personal Author:
Sajatovic, Martha ; Colon-Zimmermann, Kari ; Kahriman, Mustafa ; Fuentes-Casiano, Edna ; Liu, Hongyan ; ... More +
Sajatovic, Martha ; Colon-Zimmermann, Kari ; Kahriman, Mustafa ; Fuentes-Casiano, Edna ; Liu, Hongyan ; Tatsuoka, Curtis ; Cassidy, Kristin A. ; Lhatoo, Samden ; Einstadter, Douglas ; Chen, Peijun ; Less -
Description:
Objective: In spite of advances in care, many people with epilepsy have negative health events (NHEs) such as accidents, emergency department (ER) visits and poor quality of life. “Self-management for people with epilepsy and a history of negative health events” (SMART) is a novel group-format epilepsy self-management intervention. A community participatory approach informed the refinement of SMART which was then tested in a 6-month randomized controlled trial of SMART (N=60) vs. wait-list control (WL, N=60). Methods: Participants were adults ≥ age 18 with epilepsy and an NHE within the last six months (seizure, accident, self-harm attempt, ER visit, or hospitalization). Assessments were conducted at screening, baseline, 10 weeks and 24 weeks (six-months). Primary outcome was 6-month change in total NHE count. Additional outcomes included depression on the 9-item Patient Health Questionnaire (PHQ-9) and Montgomery-Asberg Depression Rating Scale (MADRS), quality of life on the 10-item Quality of Life in Epilepsy (QOLIE-10), functioning on the 36-item short-form health survey (SF-36), and seizure severity on the Liverpool Seizure Severity Scale. Results: Mean age was 41.3 years (SD = 11.82), 69.9% were African-American, 74.2% were unemployed and 87.4% with an annual income < U.S. $25,000. 57.5% had a seizure within 30 days of enrollment. Most NHEs were seizures. Six month study attrition was 14.2% overall and similar between arms. Individuals randomized to SMART had greater reduction in total median NHEs from baseline to 6-months compared to WL (p=.04). SMART was also associated with improved PHQ-9 (p=.032), MADRS (p= .002), QOLIE-10 (p<.001) and SF-36 (p=.015 physical health, p=.003 mental health) vs. WL. There was no difference in seizure severity. Significance: SMART is associated with reduced health complications and improved mood, quality of life and health functioning in high-risk people with epilepsy. Additional efforts are needed to investigate potential for scale-up.
Subject:
[+]
Adult
Article
Depression
Epilepsy
Female
Hospitalization
Humans
Male
Middle Aged
Prospective Studies
Quality Of Life
Seizures
Self-management
Telemedicine
Treatment Outcome
Epilepsy
Self-Management

Source:
Epilepsia. 59(9):1684-1695 ;
Pubmed ID:
30098003
Pubmed Central ID:
PMC6128290
Document Type:
Journal Article ;
Funding:
U48 DP005030/DP/NCCDPHP CDC HHS/United States ; U48DP005030/ACL HHS/United States ;
U48 DP005030/DP/NCCDPHP CDC HHS/United States ; U48DP005030/ACL HHS/United States ; Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:89d912a0f5757e6cc6807853b8c95a5f8b3114d6bab6376cda92ea93b0c14ed9
File Type:

Supporting Files

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