PDGFRA gene, maternal binge drinking and obstructive heart defects

Details

• Alternative Title:
  Sci Rep
• Personal Author:
  Tang, Xinyu ; Eberhart, Johann K. ; Cleves, Mario A. ; Li, Jingyun ; Li, Ming ; MacLeod, Stewart ; Nembhard, Wendy N. ; Hobbs, Charlotte A.
• Description:
  Obstructive heart defects (OHDs) are a major health concern worldwide. The platelet-derived growth factor (PDGF) genes are known to have regulatory functions that are essential for proper heart development. In a zebrafish model, Pdgfra was further demonstrated to interact with ethanol during craniofacial development. In this article, we investigated interactions between variants in PDGF genes and periconceptional alcohol exposure on the risk of OHDs by applying log-linear models to 806 OHD case and 995 control families enrolled in the National Birth Defects Prevention Study. The interactions between four variants in PDGFA and maternal binge drinking reached a nominal significance level. The maternal T allele of rs869978 was estimated to increase OHD risk among women who binge drink, while infant genotypes of rs2291591, rs2228230, rs1547904, and rs869978 may reduce the risk. Although none of these associations remain statistically significant after multiple testing adjustment and the estimated maternal effect may be influenced by unknown confounding factors, such as maternal smoking, these findings are consistent with previous animal studies supporting potential interactions between the PDGFRA gene and maternal alcohol exposure. Replication studies with larger sample sizes are needed to further elucidate this potential interplay and its influence on OHD risks.
• Subjects:
  Article
• Source:
  Sci Rep. 8.
• Pubmed ID:
  30038270
• Pubmed Central ID:
  PMC6056529
• Document Type:
  Journal Article
• Funding:
  R01DE020884/U.S. Department of Health & Human Services ; NIH ; National Institute of Dental and Craniofacial Research (NIDCR)/ ; U01 DD000491/DD/NCBDD CDC HHS/United States ; 5U01DD000491-05/U.S. Department of Health & Human Services ; CDC ; National Center on Birth Defects and Developmental Disabilities (NCBDDD)/ ; R01 AA023426/AA/NIAAA NIH HHS/United States ; U01DD000491/U.S. Department of Health & Human Services ; CDC ; National Center on Birth Defects and Developmental Disabilities (NCBDDD)/ ; K01 HL140333/HL/NHLBI NIH HHS/United States ; R01 DE020884/DE/NIDCR NIH HHS/United States ; R01HD039054/U.S. Department of Health & Human Services ; NIH ; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ ; R01 HD039054/HD/NICHD NIH HHS/United States ; K01HL140333/U.S. Department of Health & Human Services ; NIH ; National Heart, Lung, and Blood Institute (NHLBI)/ ; R01AA023426/U.S. Department of Health & Human Services ; NIH ; National Institute on Alcohol Abuse and Alcoholism (NIAAA)/
• Volume:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:4f93b18746d36ec7e100902e01ab6fedef1f55f8997b50d08aafcbd70ac82a2e
• Download URL:
  https://stacks.cdc.gov/view/cdc/58711/cdc_58711_DS1.pdf
• File Type:
  [PDF - 962.39 KB ]