Details:

Alternative Title:
J Atten Disord
Personal Author:
Anderson, Kayla N. ; Dutton, Annelise C. ; Broussard, Cheryl S. ; Farr, Sherry L. ; Lind, Jennifer N. ; ... More +
Anderson, Kayla N. ; Dutton, Annelise C. ; Broussard, Cheryl S. ; Farr, Sherry L. ; Lind, Jennifer N. ; Visser, Susanna N. ; Ailes, Elizabeth C. ; Shapira, Stuart K. ; Reefhuis, Jennita ; Tinker, Sarah C. Less -
Corporate Authors:
National Birth Defects Prevention Study (NBDPS)
Description:
Objective

The objective of this study was to examine the prevalence of, and maternal characteristics associated with, ADHD medication use before and during pregnancy, and associations between early pregnancy ADHD medication use and risk for 12 selected birth defects.

Method

We used data from the National Birth Defects Prevention Study (1998–2011), a U.S. population–based case-control study examining risk factors for major structural birth defects.

Results

There was an increase in ADHD medication use from 1998–1999 (0.2%) to 2010–2011 (0.5%; p < .001). Early pregnancy ADHD medication use was more commonly reported by mothers of infants/fetuses with gastroschisis (crude odds ratio [cOR]: 2.9, 95% confidence interval [CI] = [1.2, 6.9]), omphalocele (cOR: 4.0, 95% CI = [1.2, 13.6]), and transverse limb deficiency (cOR: 3.3, 95% CI = [1.1, 9.6]).

Conclusion

ADHD medication use before and during pregnancy was rare, but the prevalence of use has increased over time. In this analysis, early pregnancy ADHD medication use was associated with three of 12 selected birth defects.


Subject:
[+]
ADHD
Article
Attention Deficit Disorder With Hyperactivity
Birth Defects
Case-Control Studies
Female
Gastroschisis
Humans
Infant
Medication Use
Mothers
Odds Ratio
Pregnancy
Risk Factors
Stimulants
Pregnancy

Source:
J Atten Disord. 24(3):479-489
Pubmed ID:
29519207
Pubmed Central ID:
PMC6119527
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:95df29a143ab523621b595b62b3a85e5a8284e9210e0f071d1f5b3cb305a67e2
File Type:

Supporting Files

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