Identification of Primary Congenital Hypothyroidism Based on Two Newborn Screens — Utah, 2010–2016

Details

• Journal Article:
  Morbidity and Mortality Weekly Report (MMWR)
• Personal Author:
  Jones, David E. ; Hart, Kim ; Shapira, Stuart K. ; Murray, Mary ; Atkinson-Dunn, Robyn ; Rohrwasser, Andreas
• Description:
  Newborn screening for primary Congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). Untreated Congenital hypothyroidism can result in cognitive impairment and growth Complications (decreased height/length). Initial newborn screening for Congenital hypothyroidism is typically performed 24-48 hours after birth. Fourteen states, including Utah, perform a routine second screen at approximately 2 weeks of age.* During 2010-2016, a total of 359,432 infants in Utah were screened for Congenital hypothyroidism, and 130 cases were diagnosed; among these, 98 had an abnormal first screen, and 25 had an abnormal second screen (seven infants were excluded because of missing data). A retrospective examination of Utah's screening data indicated that 20% of Congenital hypothyroidism cases could not have been efficiently identified by a single screen alone. This study highlights the utility of a two-screen process and demonstrates that differential cutoff values for the first and second screens could optimize both screening sensitivity and specificity.
• Subjects:
  Congenital Hypothyroidism Full Report Humans Infant, Newborn Neonatal Screening Retrospective Studies Sensitivity And Specificity
• Source:
  MMWR Morbidity Mortal Weekly Rep. 67(28):782-785.
• Series:
  Weekly Report: Morbidity and Mortality Weekly Report (MMWR)
• DOI:
  http://dx.doi.org/10.15585/mmwr.mm6728a4
• ISSN:
  0149-2195 (print) ; 1545-861X (digital)
• Pubmed ID:
  30024866
• Pubmed Central ID:
  PMC6053999
• Document Type:
  Journal Article
• Place as Subject:
  Utah
• Pages in Document:
  4 pdf pages
• Volume:
  67
• Issue:
  28
• Collection(s):
  Morbidity and Mortality Weekly Report (MMWR)
• Main Document Checksum:
  urn:sha-512:cb8a32a0623d401878f623f5fdf491892a85d0243ab2113ba24abb0c54376773fb57ef837f2c98bfcaccfe2c32b5445186f2f39ddd2ae9786507c1c231db64f0
• Download URL:
  https://stacks.cdc.gov/view/cdc/58432/cdc_58432_DS1.pdf
• File Type:
  [PDF - 127.04 KB ]