Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Publisher's site:
http://dx.doi.org/10.15585/mmwr.mm6728a4
Personal Author:
Jones, David E. ; Hart, Kim ; Shapira, Stuart K. ; Murray, Mary ; Atkinson-Dunn, Robyn ; ... More +
Jones, David E. ; Hart, Kim ; Shapira, Stuart K. ; Murray, Mary ; Atkinson-Dunn, Robyn ; Rohrwasser, Andreas Less -
Description:
Newborn screening for primary congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). Untreated congenital hypothyroidism can result in cognitive impairment and growth complications (decreased height/length). Initial newborn screening for congenital hypothyroidism is typically performed 24-48 hours after birth. Fourteen states, including Utah, perform a routine second screen at approximately 2 weeks of age.* During 2010-2016, a total of 359,432 infants in Utah were screened for congenital hypothyroidism, and 130 cases were diagnosed; among these, 98 had an abnormal first screen, and 25 had an abnormal second screen (seven infants were excluded because of missing data). A retrospective examination of Utah's screening data indicated that 20% of congenital hypothyroidism cases could not have been efficiently identified by a single screen alone. This study highlights the utility of a two-screen process and demonstrates that differential cutoff values for the first and second screens could optimize both screening sensitivity and specificity.
Subject:
[+]
Congenital Hypothyroidism
Full Report
Humans
Infant, Newborn
Neonatal Screening
Retrospective Studies
Sensitivity And Specificity

Source:
MMWR Morb Mortal Wkly Rep. 67(28):782-785.
Pubmed ID:
30024866
Pubmed Central ID:
PMC6053999
Document Type:
Journal Article
Place as Subject:
Utah
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
[+]
urn:sha256:dcfedbc3817f431285d1f8e6cc77906d03a88f5f32b257a4e27662d193351654
File Type:

Supporting Files

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