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Identification of Primary Congenital Hypothyroidism Based on Two Newborn Screens — Utah, 2010–2016
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Jul 20 2018
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Source: MMWR Morbidity Mortal Weekly Rep. 67(28):782-785.
[PDF-127.04 KB]
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Journal Article:Morbidity and Mortality Weekly Report (MMWR)
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Description:Newborn screening for primary Congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). Untreated Congenital hypothyroidism can result in cognitive impairment and growth Complications (decreased height/length). Initial newborn screening for Congenital hypothyroidism is typically performed 24-48 hours after birth. Fourteen states, including Utah, perform a routine second screen at approximately 2 weeks of age.* During 2010-2016, a total of 359,432 infants in Utah were screened for Congenital hypothyroidism, and 130 cases were diagnosed; among these, 98 had an abnormal first screen, and 25 had an abnormal second screen (seven infants were excluded because of missing data). A retrospective examination of Utah's screening data indicated that 20% of Congenital hypothyroidism cases could not have been efficiently identified by a single screen alone. This study highlights the utility of a two-screen process and demonstrates that differential cutoff values for the first and second screens could optimize both screening sensitivity and specificity.
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ISSN:0149-2195 (print);1545-861X (digital);
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Pubmed ID:30024866
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Pubmed Central ID:PMC6053999
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Pages in Document:4 pdf pages
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Volume:67
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Issue:28
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